HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells

The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for cert...

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Autores principales:	Wen-Fang Wang, Li Yan, Zhao Liu, Lan-Xuan Liu, Jian Lin, Zhi-Yin Liu, Xiong-Ping Chen, Wu Zhang, Zi-Zhen Xu, Ting Shi, Jun-Min Li, Yi-Lei Zhao, Guoyu Meng, Yi Xia, Jian-Yong Li, Jiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ecd06a77cbb42a28310878c9d65a39a
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spelling	oai:doaj.org-article:1ecd06a77cbb42a28310878c9d65a39a2021-12-02T17:06:28ZHSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells10.1038/s41467-017-00476-w2041-1723https://doaj.org/article/1ecd06a77cbb42a28310878c9d65a39a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00476-whttps://doaj.org/toc/2041-1723The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas.Wen-Fang WangLi YanZhao LiuLan-Xuan LiuJian LinZhi-Yin LiuXiong-Ping ChenWu ZhangZi-Zhen XuTing ShiJun-Min LiYi-Lei ZhaoGuoyu MengYi XiaJian-Yong LiJiang ZhuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen-Fang Wang Li Yan Zhao Liu Lan-Xuan Liu Jian Lin Zhi-Yin Liu Xiong-Ping Chen Wu Zhang Zi-Zhen Xu Ting Shi Jun-Min Li Yi-Lei Zhao Guoyu Meng Yi Xia Jian-Yong Li Jiang Zhu HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
description	The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas.
format	article
author	Wen-Fang Wang Li Yan Zhao Liu Lan-Xuan Liu Jian Lin Zhi-Yin Liu Xiong-Ping Chen Wu Zhang Zi-Zhen Xu Ting Shi Jun-Min Li Yi-Lei Zhao Guoyu Meng Yi Xia Jian-Yong Li Jiang Zhu
author_facet	Wen-Fang Wang Li Yan Zhao Liu Lan-Xuan Liu Jian Lin Zhi-Yin Liu Xiong-Ping Chen Wu Zhang Zi-Zhen Xu Ting Shi Jun-Min Li Yi-Lei Zhao Guoyu Meng Yi Xia Jian-Yong Li Jiang Zhu
author_sort	Wen-Fang Wang
title	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
title_short	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
title_full	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
title_fullStr	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
title_full_unstemmed	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells
title_sort	hsp70-hrd1 axis precludes the oncorepressor potential of n-terminal misfolded blimp-1s in lymphoma cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ecd06a77cbb42a28310878c9d65a39a
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HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells

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