Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?

Abstract Background The study aimed to evaluate whether the presence of DKA at diabetes diagnosis was associated with poorer metabolic control during a 5-year follow-up. Methods The study included children treated due to newly diagnosed T1D complicated with DKA between 2010 and 2014 with a complete...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kowalczyk Emilia, Stypułkowska Aneta, Majewska Barbara, Jarzębowska Małgorzata, Hoffmann Aleksandra, Buła Paulina, Szypowska Agnieszka
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	In-patient diabetes Children and adolescents Other complications Devices Self-management Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/1ed8e6e2d1e54003bbd8a5156205e5f3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1ed8e6e2d1e54003bbd8a5156205e5f3
record_format	dspace
spelling	oai:doaj.org-article:1ed8e6e2d1e54003bbd8a5156205e5f32021-11-07T12:02:19ZIs diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?10.1186/s12902-021-00882-81472-6823https://doaj.org/article/1ed8e6e2d1e54003bbd8a5156205e5f32021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00882-8https://doaj.org/toc/1472-6823Abstract Background The study aimed to evaluate whether the presence of DKA at diabetes diagnosis was associated with poorer metabolic control during a 5-year follow-up. Methods The study included children treated due to newly diagnosed T1D complicated with DKA between 2010 and 2014 with a complete 5-year follow-up. In every case we performed individual matching for age, gender and BMI with a person without DKA (nDKA) on recognition. We collected data regarding treatment modality, HbA1C, total daily insulin dose, basal insulin and BMI-SDS. Results 85 children at the median age of 7.93 years had DKA at diabetes diagnosis. The median pH was 7.19.Continuous subcutaneous insulin infusion (CSII) was used in 87% of participants in each group. No differences in HbA1C level (7,3%vs7,2%;p = .413) were noted after 5 years of disease duration. The severity of ketoacidosis exerted no significant effect on HbA1C. The method of insulin delivery at baseline was significantly associated with HbA1C levels after 5 years of observation, βCSII = − 1.46,95%CI[− 2.01 to − 0.92],p < .001. Conclusions The presence of DKA at diabetes diagnosis is not associated with deteriorated long-term metabolic control in children using modern technologies. The early implementation of CSII into diabetes treatment may change the effect of DKA and lead to a long-term HbA1C improvement.Kowalczyk EmiliaStypułkowska AnetaMajewska BarbaraJarzębowska MałgorzataHoffmann AleksandraBuła PaulinaSzypowska AgnieszkaBMCarticleIn-patient diabetesChildren and adolescentsOther complicationsDevicesSelf-managementDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	In-patient diabetes Children and adolescents Other complications Devices Self-management Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	In-patient diabetes Children and adolescents Other complications Devices Self-management Diseases of the endocrine glands. Clinical endocrinology RC648-665 Kowalczyk Emilia Stypułkowska Aneta Majewska Barbara Jarzębowska Małgorzata Hoffmann Aleksandra Buła Paulina Szypowska Agnieszka Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
description	Abstract Background The study aimed to evaluate whether the presence of DKA at diabetes diagnosis was associated with poorer metabolic control during a 5-year follow-up. Methods The study included children treated due to newly diagnosed T1D complicated with DKA between 2010 and 2014 with a complete 5-year follow-up. In every case we performed individual matching for age, gender and BMI with a person without DKA (nDKA) on recognition. We collected data regarding treatment modality, HbA1C, total daily insulin dose, basal insulin and BMI-SDS. Results 85 children at the median age of 7.93 years had DKA at diabetes diagnosis. The median pH was 7.19.Continuous subcutaneous insulin infusion (CSII) was used in 87% of participants in each group. No differences in HbA1C level (7,3%vs7,2%;p = .413) were noted after 5 years of disease duration. The severity of ketoacidosis exerted no significant effect on HbA1C. The method of insulin delivery at baseline was significantly associated with HbA1C levels after 5 years of observation, βCSII = − 1.46,95%CI[− 2.01 to − 0.92],p < .001. Conclusions The presence of DKA at diabetes diagnosis is not associated with deteriorated long-term metabolic control in children using modern technologies. The early implementation of CSII into diabetes treatment may change the effect of DKA and lead to a long-term HbA1C improvement.
format	article
author	Kowalczyk Emilia Stypułkowska Aneta Majewska Barbara Jarzębowska Małgorzata Hoffmann Aleksandra Buła Paulina Szypowska Agnieszka
author_facet	Kowalczyk Emilia Stypułkowska Aneta Majewska Barbara Jarzębowska Małgorzata Hoffmann Aleksandra Buła Paulina Szypowska Agnieszka
author_sort	Kowalczyk Emilia
title	Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
title_short	Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
title_full	Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
title_fullStr	Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
title_full_unstemmed	Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
title_sort	is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1ed8e6e2d1e54003bbd8a5156205e5f3
work_keys_str_mv	AT kowalczykemilia isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes AT stypułkowskaaneta isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes AT majewskabarbara isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes AT jarzebowskamałgorzata isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes AT hoffmannaleksandra isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes AT bułapaulina isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes AT szypowskaagnieszka isdiabeticketoacidosisagoodpredictorof5yearmetaboliccontrolinchildrenwithnewlydiagnosedtype1diabetes
_version_	1718443534174912512

Is diabetic ketoacidosis a good predictor of 5-year metabolic control in children with newly diagnosed type 1 diabetes?

Ejemplares similares