Genomic RNA folding mediates assembly of human parechovirus

The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.

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Autores principales:	Shabih Shakeel, Eric C. Dykeman, Simon J. White, Ari Ora, Joseph J.B. Cockburn, Sarah J. Butcher, Peter G. Stockley, Reidun Twarock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1edc545ea86c44ca9bf0cec5084edbad
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spelling	oai:doaj.org-article:1edc545ea86c44ca9bf0cec5084edbad2021-12-02T14:16:31ZGenomic RNA folding mediates assembly of human parechovirus10.1038/s41467-016-0011-z2041-1723https://doaj.org/article/1edc545ea86c44ca9bf0cec5084edbad2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-016-0011-zhttps://doaj.org/toc/2041-1723The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.Shabih ShakeelEric C. DykemanSimon J. WhiteAri OraJoseph J.B. CockburnSarah J. ButcherPeter G. StockleyReidun TwarockNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shabih Shakeel Eric C. Dykeman Simon J. White Ari Ora Joseph J.B. Cockburn Sarah J. Butcher Peter G. Stockley Reidun Twarock Genomic RNA folding mediates assembly of human parechovirus
description	The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specific interactions for virion assembly.
format	article
author	Shabih Shakeel Eric C. Dykeman Simon J. White Ari Ora Joseph J.B. Cockburn Sarah J. Butcher Peter G. Stockley Reidun Twarock
author_facet	Shabih Shakeel Eric C. Dykeman Simon J. White Ari Ora Joseph J.B. Cockburn Sarah J. Butcher Peter G. Stockley Reidun Twarock
author_sort	Shabih Shakeel
title	Genomic RNA folding mediates assembly of human parechovirus
title_short	Genomic RNA folding mediates assembly of human parechovirus
title_full	Genomic RNA folding mediates assembly of human parechovirus
title_fullStr	Genomic RNA folding mediates assembly of human parechovirus
title_full_unstemmed	Genomic RNA folding mediates assembly of human parechovirus
title_sort	genomic rna folding mediates assembly of human parechovirus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1edc545ea86c44ca9bf0cec5084edbad
work_keys_str_mv	AT shabihshakeel genomicrnafoldingmediatesassemblyofhumanparechovirus AT ericcdykeman genomicrnafoldingmediatesassemblyofhumanparechovirus AT simonjwhite genomicrnafoldingmediatesassemblyofhumanparechovirus AT ariora genomicrnafoldingmediatesassemblyofhumanparechovirus AT josephjbcockburn genomicrnafoldingmediatesassemblyofhumanparechovirus AT sarahjbutcher genomicrnafoldingmediatesassemblyofhumanparechovirus AT petergstockley genomicrnafoldingmediatesassemblyofhumanparechovirus AT reiduntwarock genomicrnafoldingmediatesassemblyofhumanparechovirus
_version_	1718391653745557504

Genomic RNA folding mediates assembly of human parechovirus

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