The determinants of lipid profiles in early adolescence in a Ugandan birth cohort

Abstract Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participa...

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Autores principales:	Jan Pieter R. Koopman, Swaib A. Lule, Christopher Zziwa, Hellen Akurut, Lawrence Lubyayi, Margaret Nampijja, Florence Akello, Priscilla Balungi, Josephine Tumusiime, Gloria Oduru, Alison M. Elliott, Emily L. Webb, John Bradley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1ee8bd45884b4beb8166c621da630c6e
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spelling	oai:doaj.org-article:1ee8bd45884b4beb8166c621da630c6e2021-12-02T18:50:47ZThe determinants of lipid profiles in early adolescence in a Ugandan birth cohort10.1038/s41598-021-96035-x2045-2322https://doaj.org/article/1ee8bd45884b4beb8166c621da630c6e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96035-xhttps://doaj.org/toc/2045-2322Abstract Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participants in the Entebbe Mother and Baby Study, we used linear regression to examine whether prenatal, childhood or adolescent factors are associated with lipid levels. Reduced high-density lipoprotein (HDL) and elevated triglyceride levels were common (prevalence 31% and 14%, respectively), but elevated low-density lipoprotein (LDL) or total cholesterol (TC) were rare. Current malaria infection was associated with lower mean LDL (adjusted ß − 0.51; 95% CI − 0.81, − 0.21), HDL (adjusted ß − 0.40; 95% CI − 0.56, − 0.23), and TC levels (adjusted ß − 0.62; 95% CI − 0.97, − 0.27), but higher mean triglyceride levels (geometric mean ratio (GMR) 1.47; 95% CI 1.18–1.84). Early-life asymptomatic malaria was associated with modest reductions in HDL and TC. Body mass index (BMI) was positively associated with LDL, TC, and triglycerides. No associations with helminth infection were found. Our findings suggest that early-life factors have only marginal effects on the lipid profile. Current malaria infection and BMI are strongly associated with lipids and important to consider when trying to improve the lipid profile.Jan Pieter R. KoopmanSwaib A. LuleChristopher ZziwaHellen AkurutLawrence LubyayiMargaret NampijjaFlorence AkelloPriscilla BalungiJosephine TumusiimeGloria OduruAlison M. ElliottEmily L. WebbJohn BradleyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Pieter R. Koopman Swaib A. Lule Christopher Zziwa Hellen Akurut Lawrence Lubyayi Margaret Nampijja Florence Akello Priscilla Balungi Josephine Tumusiime Gloria Oduru Alison M. Elliott Emily L. Webb John Bradley The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
description	Abstract Dyslipidaemia in adolescence tracks into adulthood and is an important risk factor for cardiovascular disease. Little is known about the effects of environmental exposures and early-life exposure to infectious diseases common to tropical regions on lipids. In 1119 early adolescent participants in the Entebbe Mother and Baby Study, we used linear regression to examine whether prenatal, childhood or adolescent factors are associated with lipid levels. Reduced high-density lipoprotein (HDL) and elevated triglyceride levels were common (prevalence 31% and 14%, respectively), but elevated low-density lipoprotein (LDL) or total cholesterol (TC) were rare. Current malaria infection was associated with lower mean LDL (adjusted ß − 0.51; 95% CI − 0.81, − 0.21), HDL (adjusted ß − 0.40; 95% CI − 0.56, − 0.23), and TC levels (adjusted ß − 0.62; 95% CI − 0.97, − 0.27), but higher mean triglyceride levels (geometric mean ratio (GMR) 1.47; 95% CI 1.18–1.84). Early-life asymptomatic malaria was associated with modest reductions in HDL and TC. Body mass index (BMI) was positively associated with LDL, TC, and triglycerides. No associations with helminth infection were found. Our findings suggest that early-life factors have only marginal effects on the lipid profile. Current malaria infection and BMI are strongly associated with lipids and important to consider when trying to improve the lipid profile.
format	article
author	Jan Pieter R. Koopman Swaib A. Lule Christopher Zziwa Hellen Akurut Lawrence Lubyayi Margaret Nampijja Florence Akello Priscilla Balungi Josephine Tumusiime Gloria Oduru Alison M. Elliott Emily L. Webb John Bradley
author_facet	Jan Pieter R. Koopman Swaib A. Lule Christopher Zziwa Hellen Akurut Lawrence Lubyayi Margaret Nampijja Florence Akello Priscilla Balungi Josephine Tumusiime Gloria Oduru Alison M. Elliott Emily L. Webb John Bradley
author_sort	Jan Pieter R. Koopman
title	The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
title_short	The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
title_full	The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
title_fullStr	The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
title_full_unstemmed	The determinants of lipid profiles in early adolescence in a Ugandan birth cohort
title_sort	determinants of lipid profiles in early adolescence in a ugandan birth cohort
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ee8bd45884b4beb8166c621da630c6e
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The determinants of lipid profiles in early adolescence in a Ugandan birth cohort

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