Synergistic effect of nanotopography and bioactive ions on peri-implant bone response

Yingmin Su,1 Satoshi Komasa,1 Peiqi Li,2 Mariko Nishizaki,1 Luyuan Chen,1 Chisato Terada,1 Shigeki Yoshimine,1 Hiroshi Nishizaki,1 Joji Okazaki1 1Department of Removable Prosthodontics and Occlusion, 2Department of Oral Implantology, Osaka Dental University, Hirakata, Osaka, Japan Abstract: Both b...

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Autores principales:	Su Y, Komasa S, Li P, Nishizaki M, Chen L, Terada C, Yoshimine S, Nishizaki H, Okazaki J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	surface modification nanotopography bioactive ion osteoinduction osseointegration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1eee40b081ee44cf8bbb6e18bafbf08e
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spelling	oai:doaj.org-article:1eee40b081ee44cf8bbb6e18bafbf08e2021-12-02T05:10:46ZSynergistic effect of nanotopography and bioactive ions on peri-implant bone response1178-2013https://doaj.org/article/1eee40b081ee44cf8bbb6e18bafbf08e2017-01-01T00:00:00Zhttps://www.dovepress.com/synergistic-effect-of-nanotopography-and-bioactive-ions-on-peri-implan-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yingmin Su,1 Satoshi Komasa,1 Peiqi Li,2 Mariko Nishizaki,1 Luyuan Chen,1 Chisato Terada,1 Shigeki Yoshimine,1 Hiroshi Nishizaki,1 Joji Okazaki1 1Department of Removable Prosthodontics and Occlusion, 2Department of Oral Implantology, Osaka Dental University, Hirakata, Osaka, Japan Abstract: Both bioactive ion chemistry and nanoscale surface modifications are beneficial for enhanced osseointegration of endosseous implants. In this study, a facile synthesis approach to the incorporation of bioactive Ca2+ ions into the interlayers of nanoporous structures (Ca-nano) formed on a Ti6Al4V alloy surface was developed by sequential chemical and heat treatments. Samples with a machined surface and an Na+ ion-incorporated nanoporous surface (Na-nano) fabricated by concentrated alkali and heat treatment were used in parallel for comparison. The bone response was investigated by microcomputed tomography assessment, sequential fluorescent labeling analysis, and histological and histomorphometric evaluation after 8 weeks of implantation in rat femurs. No significant differences were found in the nanotopography, surface roughness, or crystalline properties of the Ca-nano and Na-nano surfaces. Bone–implant contact was better in the Ca-nano and Na-nano implants than in the machined implant. The Ca-nano implant was superior to the Na-nano implant in terms of enhancing the volume of new bone formation. The bone formation activity consistently increased for the Ca-nano implant but ceased for the Na-nano implant in the late healing stage. These results suggest that Ca-nano implants have promising potential for application in dentistry and orthopedics. Keywords: surface modification, nanotopography, bioactive ion, osteoinduction, osseointegrationSu YKomasa SLi PNishizaki MChen LTerada CYoshimine SNishizaki HOkazaki JDove Medical Pressarticlesurface modificationnanotopographybioactive ionosteoinductionosseointegrationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 925-934 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	surface modification nanotopography bioactive ion osteoinduction osseointegration Medicine (General) R5-920
spellingShingle	surface modification nanotopography bioactive ion osteoinduction osseointegration Medicine (General) R5-920 Su Y Komasa S Li P Nishizaki M Chen L Terada C Yoshimine S Nishizaki H Okazaki J Synergistic effect of nanotopography and bioactive ions on peri-implant bone response
description	Yingmin Su,1 Satoshi Komasa,1 Peiqi Li,2 Mariko Nishizaki,1 Luyuan Chen,1 Chisato Terada,1 Shigeki Yoshimine,1 Hiroshi Nishizaki,1 Joji Okazaki1 1Department of Removable Prosthodontics and Occlusion, 2Department of Oral Implantology, Osaka Dental University, Hirakata, Osaka, Japan Abstract: Both bioactive ion chemistry and nanoscale surface modifications are beneficial for enhanced osseointegration of endosseous implants. In this study, a facile synthesis approach to the incorporation of bioactive Ca2+ ions into the interlayers of nanoporous structures (Ca-nano) formed on a Ti6Al4V alloy surface was developed by sequential chemical and heat treatments. Samples with a machined surface and an Na+ ion-incorporated nanoporous surface (Na-nano) fabricated by concentrated alkali and heat treatment were used in parallel for comparison. The bone response was investigated by microcomputed tomography assessment, sequential fluorescent labeling analysis, and histological and histomorphometric evaluation after 8 weeks of implantation in rat femurs. No significant differences were found in the nanotopography, surface roughness, or crystalline properties of the Ca-nano and Na-nano surfaces. Bone–implant contact was better in the Ca-nano and Na-nano implants than in the machined implant. The Ca-nano implant was superior to the Na-nano implant in terms of enhancing the volume of new bone formation. The bone formation activity consistently increased for the Ca-nano implant but ceased for the Na-nano implant in the late healing stage. These results suggest that Ca-nano implants have promising potential for application in dentistry and orthopedics. Keywords: surface modification, nanotopography, bioactive ion, osteoinduction, osseointegration
format	article
author	Su Y Komasa S Li P Nishizaki M Chen L Terada C Yoshimine S Nishizaki H Okazaki J
author_facet	Su Y Komasa S Li P Nishizaki M Chen L Terada C Yoshimine S Nishizaki H Okazaki J
author_sort	Su Y
title	Synergistic effect of nanotopography and bioactive ions on peri-implant bone response
title_short	Synergistic effect of nanotopography and bioactive ions on peri-implant bone response
title_full	Synergistic effect of nanotopography and bioactive ions on peri-implant bone response
title_fullStr	Synergistic effect of nanotopography and bioactive ions on peri-implant bone response
title_full_unstemmed	Synergistic effect of nanotopography and bioactive ions on peri-implant bone response
title_sort	synergistic effect of nanotopography and bioactive ions on peri-implant bone response
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/1eee40b081ee44cf8bbb6e18bafbf08e
work_keys_str_mv	AT suy synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT komasas synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT lip synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT nishizakim synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT chenl synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT teradac synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT yoshimines synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT nishizakih synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse AT okazakij synergisticeffectofnanotopographyandbioactiveionsonperiimplantboneresponse
_version_	1718400518262358016

Synergistic effect of nanotopography and bioactive ions on peri-implant bone response

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