Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.

In the event of a novel influenza A virus pandemic, prophylaxis mediated by antibodies provides an adjunct control option to vaccines and antivirals. This strategy is particularly pertinent to unvaccinated populations at risk during the lag time to produce and distribute an effective vaccine. Theref...

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Autores principales:	Catherine Rinaldi, William J Penhale, Philip A Stumbles, Guan Tay, Cassandra M Berry
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1eeeb4e8804a4ea48cfef369b256d9f7
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spelling	oai:doaj.org-article:1eeeb4e8804a4ea48cfef369b256d9f72021-11-18T08:30:30ZModulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.1932-620310.1371/journal.pone.0089674https://doaj.org/article/1eeeb4e8804a4ea48cfef369b256d9f72014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586955/?tool=EBIhttps://doaj.org/toc/1932-6203In the event of a novel influenza A virus pandemic, prophylaxis mediated by antibodies provides an adjunct control option to vaccines and antivirals. This strategy is particularly pertinent to unvaccinated populations at risk during the lag time to produce and distribute an effective vaccine. Therefore, development of effective prophylactic therapies is of high importance. Although previous approaches have used systemic delivery of monoclonal antibodies or convalescent sera, available supply is a serious limitation. Here, we have investigated intranasal delivery of influenza-specific ovine polyclonal IgG antibodies for their efficacy against homologous influenza virus challenge in a mouse model. Both influenza-specific IgG and F(ab')2 reduced clinical scores, body weight loss and lung viral loads in mice treated 1 hour before virus exposure. Full protection from disease was also observed when antibody was delivered up to 3 days prior to virus infection. Furthermore, effective prophylaxis was independent of a strong innate immune response. This strategy presents a further option for prophylactic intervention against influenza A virus using ruminants to generate a bulk supply that could potentially be used in a pandemic setting, to slow virus transmission and reduce morbidity associated with a high cytokine phenotype.Catherine RinaldiWilliam J PenhalePhilip A StumblesGuan TayCassandra M BerryPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89674 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine Rinaldi William J Penhale Philip A Stumbles Guan Tay Cassandra M Berry Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
description	In the event of a novel influenza A virus pandemic, prophylaxis mediated by antibodies provides an adjunct control option to vaccines and antivirals. This strategy is particularly pertinent to unvaccinated populations at risk during the lag time to produce and distribute an effective vaccine. Therefore, development of effective prophylactic therapies is of high importance. Although previous approaches have used systemic delivery of monoclonal antibodies or convalescent sera, available supply is a serious limitation. Here, we have investigated intranasal delivery of influenza-specific ovine polyclonal IgG antibodies for their efficacy against homologous influenza virus challenge in a mouse model. Both influenza-specific IgG and F(ab')2 reduced clinical scores, body weight loss and lung viral loads in mice treated 1 hour before virus exposure. Full protection from disease was also observed when antibody was delivered up to 3 days prior to virus infection. Furthermore, effective prophylaxis was independent of a strong innate immune response. This strategy presents a further option for prophylactic intervention against influenza A virus using ruminants to generate a bulk supply that could potentially be used in a pandemic setting, to slow virus transmission and reduce morbidity associated with a high cytokine phenotype.
format	article
author	Catherine Rinaldi William J Penhale Philip A Stumbles Guan Tay Cassandra M Berry
author_facet	Catherine Rinaldi William J Penhale Philip A Stumbles Guan Tay Cassandra M Berry
author_sort	Catherine Rinaldi
title	Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
title_short	Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
title_full	Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
title_fullStr	Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
title_full_unstemmed	Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
title_sort	modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1eeeb4e8804a4ea48cfef369b256d9f7
work_keys_str_mv	AT catherinerinaldi modulationofinnateimmuneresponsesbyinfluenzaspecificovinepolyclonalantibodiesusedforprophylaxis AT williamjpenhale modulationofinnateimmuneresponsesbyinfluenzaspecificovinepolyclonalantibodiesusedforprophylaxis AT philipastumbles modulationofinnateimmuneresponsesbyinfluenzaspecificovinepolyclonalantibodiesusedforprophylaxis AT guantay modulationofinnateimmuneresponsesbyinfluenzaspecificovinepolyclonalantibodiesusedforprophylaxis AT cassandramberry modulationofinnateimmuneresponsesbyinfluenzaspecificovinepolyclonalantibodiesusedforprophylaxis
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Modulation of innate immune responses by influenza-specific ovine polyclonal antibodies used for prophylaxis.

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