Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in telomere/immunologic protein profiles whereas inhi...

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Autores principales:	Eun Young Yu, Syed S. Zahid, Sarah Aloe, Erik Falck-Pedersen, Xi Kathy Zhou, Nai-Kong V. Cheung, Neal F. Lue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1eeed91d3da54a22addff8ebe245c52a
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spelling	oai:doaj.org-article:1eeed91d3da54a22addff8ebe245c52a2021-11-21T12:08:38ZReciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology10.1038/s42003-021-02821-82399-3642https://doaj.org/article/1eeed91d3da54a22addff8ebe245c52a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02821-8https://doaj.org/toc/2399-3642Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in telomere/immunologic protein profiles whereas inhibiting telomerase activity in ADRN cells induces reversible conversion into MES cells.Eun Young YuSyed S. ZahidSarah AloeErik Falck-PedersenXi Kathy ZhouNai-Kong V. CheungNeal F. LueNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eun Young Yu Syed S. Zahid Sarah Aloe Erik Falck-Pedersen Xi Kathy Zhou Nai-Kong V. Cheung Neal F. Lue Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
description	Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in telomere/immunologic protein profiles whereas inhibiting telomerase activity in ADRN cells induces reversible conversion into MES cells.
format	article
author	Eun Young Yu Syed S. Zahid Sarah Aloe Erik Falck-Pedersen Xi Kathy Zhou Nai-Kong V. Cheung Neal F. Lue
author_facet	Eun Young Yu Syed S. Zahid Sarah Aloe Erik Falck-Pedersen Xi Kathy Zhou Nai-Kong V. Cheung Neal F. Lue
author_sort	Eun Young Yu
title	Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
title_short	Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
title_full	Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
title_fullStr	Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
title_full_unstemmed	Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology
title_sort	reciprocal impacts of telomerase activity and adrn/mes differentiation state in neuroblastoma tumor biology
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1eeed91d3da54a22addff8ebe245c52a
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_version_	1718419172274208768

Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

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