AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE

Environmental conditions may be a prerequisite for the development of various pathological processes in individuals living in environmentally disadvantaged areas. The respiratory system is the first target of the pollutants. Therefore, respiratory diseases occupy the first place in the overall morbi...

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Autores principales:	L. B. Masnaviyeva, I. V. Tikhonova, I. V. Kudayeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	auto-antibodies teenagers immunity air pollution Science Q
Acceso en línea:	https://doaj.org/article/1ef02cdf0fb94cb9810a189b757dcc88
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spelling	oai:doaj.org-article:1ef02cdf0fb94cb9810a189b757dcc882021-11-23T06:14:26ZAUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE2541-94202587-9596https://doaj.org/article/1ef02cdf0fb94cb9810a189b757dcc882013-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1459https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Environmental conditions may be a prerequisite for the development of various pathological processes in individuals living in environmentally disadvantaged areas. The respiratory system is the first target of the pollutants. Therefore, respiratory diseases occupy the first place in the overall morbidity. The aim of this work was to study the content of autoantibodies in blood serum of teenagers with chronic disease of the upper respiratory tract, living in air pollution emissions of the petrochemical industry. Teenagers from industrial center living near petrochemical company and "sleeping areas" were examined. Otolaryngologist conducted a survey to assess the state of the upper respiratory tract (URT). In each of the areas individuals with and without chronic diseases of the URT were isolated. The content of IgG antibodies in the serum to antigens that characterizes the general state of the immune system (the native DNA, p2-glycoprotein I, Fc-fragment of IgG) was studied by enzyme immunoassay. Statistical processing of the results was performed using nonparametric methods software package «Statistica 6.0». Diseases of the respiratory system take the first place (42.9 %) in the structure of morbidity level. According to anamnestic data more often were the following disorders: chronic tonsillitis (18,9 ± 2,6 %), chronic pharyngitis (6,8 ± 1,7 %), acute respiratory infections (42,3 ± 3,32 %). Comparison of the incidence of chronic diseases of the upper respiratory tract infections in teenagers found that cases of chronic tonsillitis were observed in 45,0 ± 4,9 % of schoolchildren living near the industrial plant and 33,3 ± 4,3 % of teenagers from residential areas, cases of chronic pharyngitis - in 12,7± 3,3 % and5± 1,9 %, respectively. In teenagers from the «sleeping areas» with chronic diseases of the URT the level of auto-antibodies to p2-glycoprotein I was lower than one in healthy children from the same area due to the greater number of cases of lower values. In the group of teenagers with chronic diseases of the URTfrom environmentally disadvantaged areas children with high content of antibodies to p2-glycoprotein I were more common than in the groups of healthy teenagers living in the same area. The findings suggest that there is activation of the immune system in healthy schoolchildren living in a «sleeping areas" of the industrial city. It can be assumed that the detected changes in the content of autoantibodies may indicate features for the adaptive processes under development pressure because of the surveyed students identified isolated cases of hypo- or hyperimmunoreactivity of specific autoantibodies.L. B. MasnaviyevaI. V. TikhonovaI. V. KudayevaScientific Сentre for Family Health and Human Reproduction Problemsarticleauto-antibodiesteenagersimmunityair pollutionScienceQRUActa Biomedica Scientifica, Vol 0, Iss 2(2), Pp 119-123 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	auto-antibodies teenagers immunity air pollution Science Q
spellingShingle	auto-antibodies teenagers immunity air pollution Science Q L. B. Masnaviyeva I. V. Tikhonova I. V. Kudayeva AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE
description	Environmental conditions may be a prerequisite for the development of various pathological processes in individuals living in environmentally disadvantaged areas. The respiratory system is the first target of the pollutants. Therefore, respiratory diseases occupy the first place in the overall morbidity. The aim of this work was to study the content of autoantibodies in blood serum of teenagers with chronic disease of the upper respiratory tract, living in air pollution emissions of the petrochemical industry. Teenagers from industrial center living near petrochemical company and "sleeping areas" were examined. Otolaryngologist conducted a survey to assess the state of the upper respiratory tract (URT). In each of the areas individuals with and without chronic diseases of the URT were isolated. The content of IgG antibodies in the serum to antigens that characterizes the general state of the immune system (the native DNA, p2-glycoprotein I, Fc-fragment of IgG) was studied by enzyme immunoassay. Statistical processing of the results was performed using nonparametric methods software package «Statistica 6.0». Diseases of the respiratory system take the first place (42.9 %) in the structure of morbidity level. According to anamnestic data more often were the following disorders: chronic tonsillitis (18,9 ± 2,6 %), chronic pharyngitis (6,8 ± 1,7 %), acute respiratory infections (42,3 ± 3,32 %). Comparison of the incidence of chronic diseases of the upper respiratory tract infections in teenagers found that cases of chronic tonsillitis were observed in 45,0 ± 4,9 % of schoolchildren living near the industrial plant and 33,3 ± 4,3 % of teenagers from residential areas, cases of chronic pharyngitis - in 12,7± 3,3 % and5± 1,9 %, respectively. In teenagers from the «sleeping areas» with chronic diseases of the URT the level of auto-antibodies to p2-glycoprotein I was lower than one in healthy children from the same area due to the greater number of cases of lower values. In the group of teenagers with chronic diseases of the URTfrom environmentally disadvantaged areas children with high content of antibodies to p2-glycoprotein I were more common than in the groups of healthy teenagers living in the same area. The findings suggest that there is activation of the immune system in healthy schoolchildren living in a «sleeping areas" of the industrial city. It can be assumed that the detected changes in the content of autoantibodies may indicate features for the adaptive processes under development pressure because of the surveyed students identified isolated cases of hypo- or hyperimmunoreactivity of specific autoantibodies.
format	article
author	L. B. Masnaviyeva I. V. Tikhonova I. V. Kudayeva
author_facet	L. B. Masnaviyeva I. V. Tikhonova I. V. Kudayeva
author_sort	L. B. Masnaviyeva
title	AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE
title_short	AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE
title_full	AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE
title_fullStr	AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE
title_full_unstemmed	AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE
title_sort	autoantibodies contents of teenagers with chronic diseases of the upper respiratory tract living in the industrial centre
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/1ef02cdf0fb94cb9810a189b757dcc88
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AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE

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