Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children

Background: Hepatitis C virus [HCV] infection is a global health problem. Children with certain risk factors are at high risk of infection.Objective: The present study aimed to evaluate the prevalence of HCV among high-risk Egyptian children.Methods: The study included 1357 children aged 3-15 years...

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Autores principales:	Mahmoud Hodeib, Alzhraa Fahmy, Gamal Taha, Mostafa Sheemy, Manar Ali
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	hepatitis c infection perinatal transmission hepatitis screening Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1ef07c874819482dabd993ef0c4f1d36
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spelling	oai:doaj.org-article:1ef07c874819482dabd993ef0c4f1d362021-12-02T19:33:14ZPrevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children2636-41742682-378010.21608/ijma.2021.76789.1314https://doaj.org/article/1ef07c874819482dabd993ef0c4f1d362021-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_192393_bf1ed4a8de721ea997cd71d0367c25cc.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Hepatitis C virus [HCV] infection is a global health problem. Children with certain risk factors are at high risk of infection.Objective: The present study aimed to evaluate the prevalence of HCV among high-risk Egyptian children.Methods: The study included 1357 children aged 3-15 years with risk factors of HCV including receiving blood products, hemodialysis, previous surgical intervention, insulin therapy and positive family history. They were subjected to careful history taking, thorough clinical examination and routine laboratory investigations. All children were tested for HCV antibodies using commercial 4th generation enzyme-linked immunosorbent assay [ELISA] kits. Those with positive results were further assessed using polymerase chain reaction [PCR].Results: Among the studied patients, there were 89 children [6.6 %] with positive HCV Ab and 73 children [5.4 %] with positive PCR test for HCV. Using multivariate logistic regression, significant predictors of HCV infection in the studied children were blood transfusion [OR: 1.23, CI: 0.019-13.4], Intravenous [IV] injection [OR: 10.962, CI: 1.937-62.026] and previous operation [OR: 3.12, CI: 1.046-31.6].Conclusion: HCV infection is highly prevalent among high-risk children. Blood transfusion, IV injection and exposure to surgery are independent risk factors for infection in this population.Mahmoud HodeibAlzhraa FahmyGamal TahaMostafa SheemyManar AliAl-Azhar University, Faculty of Medicine (Damietta)articlehepatitis c infectionperinatal transmissionhepatitis screeningMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 4, Pp 1792-1796 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis c infection perinatal transmission hepatitis screening Medicine (General) R5-920
spellingShingle	hepatitis c infection perinatal transmission hepatitis screening Medicine (General) R5-920 Mahmoud Hodeib Alzhraa Fahmy Gamal Taha Mostafa Sheemy Manar Ali Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children
description	Background: Hepatitis C virus [HCV] infection is a global health problem. Children with certain risk factors are at high risk of infection.Objective: The present study aimed to evaluate the prevalence of HCV among high-risk Egyptian children.Methods: The study included 1357 children aged 3-15 years with risk factors of HCV including receiving blood products, hemodialysis, previous surgical intervention, insulin therapy and positive family history. They were subjected to careful history taking, thorough clinical examination and routine laboratory investigations. All children were tested for HCV antibodies using commercial 4th generation enzyme-linked immunosorbent assay [ELISA] kits. Those with positive results were further assessed using polymerase chain reaction [PCR].Results: Among the studied patients, there were 89 children [6.6 %] with positive HCV Ab and 73 children [5.4 %] with positive PCR test for HCV. Using multivariate logistic regression, significant predictors of HCV infection in the studied children were blood transfusion [OR: 1.23, CI: 0.019-13.4], Intravenous [IV] injection [OR: 10.962, CI: 1.937-62.026] and previous operation [OR: 3.12, CI: 1.046-31.6].Conclusion: HCV infection is highly prevalent among high-risk children. Blood transfusion, IV injection and exposure to surgery are independent risk factors for infection in this population.
format	article
author	Mahmoud Hodeib Alzhraa Fahmy Gamal Taha Mostafa Sheemy Manar Ali
author_facet	Mahmoud Hodeib Alzhraa Fahmy Gamal Taha Mostafa Sheemy Manar Ali
author_sort	Mahmoud Hodeib
title	Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children
title_short	Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children
title_full	Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children
title_fullStr	Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children
title_full_unstemmed	Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children
title_sort	prevalence and risk factors of hepatitis c virus infection among high-risk egyptian children
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/1ef07c874819482dabd993ef0c4f1d36
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Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children

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