Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive <named-content content-type="genus-species">Escherichia coli</named-content> Bacteria Associated with Crohn's Disease

Development of Heptylmannoside-Based Glycoconjugate Antiadhesive Compounds against Adherent-Invasive <named-content content-type="genus-species">Escherichia coli</named-content> Bacteria Associated with Crohn's Disease

ABSTRACT The ileal lesions of Crohn's disease (CD) patients are colonized by adherent-invasive Escherichia coli (AIEC) bacteria. These bacteria adhere to mannose residues expressed by CEACAM6 on host cells in a type 1 pilus-dependent manner. In this study, we investigated different antagonists...

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Autores principales: Adeline Sivignon, Xibo Yan, Dimitri Alvarez Dorta, Richard Bonnet, Julie Bouckaert, Etienne Fleury, Julien Bernard, Sébastien G. Gouin, Arlette Darfeuille-Michaud, Nicolas Barnich
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/1ef07e44bddd4567876566ae20c1d360
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