Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

Corneal epithelium shares similar molecular signatures to other stratified epithelia. Here, the authors map super-enhancers and accessible chromatin in corneal epithelium, identifying a transcription regulatory circuit, including RUNX1, PAX6, and SMAD3, required for corneal epithelial identity and h...

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Autores principales:	Mingsen Li, Huaxing Huang, Lingyu Li, Chenxi He, Liqiong Zhu, Huizhen Guo, Li Wang, Jiafeng Liu, Siqi Wu, Jingxin Liu, Tao Xu, Zhen Mao, Nan Cao, Kang Zhang, Fei Lan, Junjun Ding, Jin Yuan, Yizhi Liu, Hong Ouyang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ef2ff68b9834f349529dd426ea394f7
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spelling	oai:doaj.org-article:1ef2ff68b9834f349529dd426ea394f72021-12-02T14:18:55ZCore transcription regulatory circuitry orchestrates corneal epithelial homeostasis10.1038/s41467-020-20713-z2041-1723https://doaj.org/article/1ef2ff68b9834f349529dd426ea394f72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20713-zhttps://doaj.org/toc/2041-1723Corneal epithelium shares similar molecular signatures to other stratified epithelia. Here, the authors map super-enhancers and accessible chromatin in corneal epithelium, identifying a transcription regulatory circuit, including RUNX1, PAX6, and SMAD3, required for corneal epithelial identity and homeostasis.Mingsen LiHuaxing HuangLingyu LiChenxi HeLiqiong ZhuHuizhen GuoLi WangJiafeng LiuSiqi WuJingxin LiuTao XuZhen MaoNan CaoKang ZhangFei LanJunjun DingJin YuanYizhi LiuHong OuyangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingsen Li Huaxing Huang Lingyu Li Chenxi He Liqiong Zhu Huizhen Guo Li Wang Jiafeng Liu Siqi Wu Jingxin Liu Tao Xu Zhen Mao Nan Cao Kang Zhang Fei Lan Junjun Ding Jin Yuan Yizhi Liu Hong Ouyang Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
description	Corneal epithelium shares similar molecular signatures to other stratified epithelia. Here, the authors map super-enhancers and accessible chromatin in corneal epithelium, identifying a transcription regulatory circuit, including RUNX1, PAX6, and SMAD3, required for corneal epithelial identity and homeostasis.
format	article
author	Mingsen Li Huaxing Huang Lingyu Li Chenxi He Liqiong Zhu Huizhen Guo Li Wang Jiafeng Liu Siqi Wu Jingxin Liu Tao Xu Zhen Mao Nan Cao Kang Zhang Fei Lan Junjun Ding Jin Yuan Yizhi Liu Hong Ouyang
author_facet	Mingsen Li Huaxing Huang Lingyu Li Chenxi He Liqiong Zhu Huizhen Guo Li Wang Jiafeng Liu Siqi Wu Jingxin Liu Tao Xu Zhen Mao Nan Cao Kang Zhang Fei Lan Junjun Ding Jin Yuan Yizhi Liu Hong Ouyang
author_sort	Mingsen Li
title	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_short	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_full	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_fullStr	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_full_unstemmed	Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
title_sort	core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1ef2ff68b9834f349529dd426ea394f7
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Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

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