NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

Activation of the NLRP3 inflammasome is associated with various diseases but its activation mechanism is not fully understood. Here, the authors determine the impact of different NLRP3 domains on sensing NLRP3 triggers, inflammasome assembly and regulation of NLRP3 inflammasome activation.

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Autores principales: Iva Hafner-Bratkovič, Petra Sušjan, Duško Lainšček, Ana Tapia-Abellán, Kosta Cerović, Lucija Kadunc, Diego Angosto-Bazarra, Pablo Pelegrin, Roman Jerala
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/1ef3edb735df4712b0a5732ea7fa1100
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