EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY

Peripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expres...

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Autores principales:	V. A. Mikhaylova, Y. S. Klimovskaya, N. V. Amanova, M. S. Zaynulina, S. A. Selkov, D. I. Sokolov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	monocytes adhesion molecules pregnancy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1ef47a6792b541e28cace2539b7e2ec2
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spelling	oai:doaj.org-article:1ef47a6792b541e28cace2539b7e2ec22021-11-18T08:03:38ZEXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY1563-06252313-741X10.15789/1563-0625-2010-4-5-337-342https://doaj.org/article/1ef47a6792b541e28cace2539b7e2ec22014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/150https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XPeripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expression of CD11a, CD11b, CD11c, CD18, CD49d, CD29 markers of monocytes from non-pregnant and pregnant women. Expression of adhesion molecules on monocytes was analyzed by flow cytometry. The amounts of CD11b-expressing monocytes increased during pregnancy, as compared with non-pregnant women. Intensity of CD11a, CD11b, CD11c, CD29 expression on the monocytes did also increase at normal pregnancy. These results suggest that intense adhesion of monocytes to endothelium during uncomplicated pregnancy may be determined by increased expression of CD11a, CD11b, CD11c, CD29, and higher amounts of CD11b+ monocytes.V. A. MikhaylovaY. S. KlimovskayaN. V. AmanovaM. S. ZaynulinaS. A. SelkovD. I. SokolovSPb RAACIarticlemonocytesadhesion moleculespregnancyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 337-342 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	monocytes adhesion molecules pregnancy Immunologic diseases. Allergy RC581-607
spellingShingle	monocytes adhesion molecules pregnancy Immunologic diseases. Allergy RC581-607 V. A. Mikhaylova Y. S. Klimovskaya N. V. Amanova M. S. Zaynulina S. A. Selkov D. I. Sokolov EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
description	Peripheral blood monocytes play a key role in regulation of immune response during pregnancy. Intensive adhesion of monocytes to endothelium proves that monocytes are activated during pregnancy. To determine a potential role of adhesion molecules for ability of monocytes to adhere, we studied expression of CD11a, CD11b, CD11c, CD18, CD49d, CD29 markers of monocytes from non-pregnant and pregnant women. Expression of adhesion molecules on monocytes was analyzed by flow cytometry. The amounts of CD11b-expressing monocytes increased during pregnancy, as compared with non-pregnant women. Intensity of CD11a, CD11b, CD11c, CD29 expression on the monocytes did also increase at normal pregnancy. These results suggest that intense adhesion of monocytes to endothelium during uncomplicated pregnancy may be determined by increased expression of CD11a, CD11b, CD11c, CD29, and higher amounts of CD11b+ monocytes.
format	article
author	V. A. Mikhaylova Y. S. Klimovskaya N. V. Amanova M. S. Zaynulina S. A. Selkov D. I. Sokolov
author_facet	V. A. Mikhaylova Y. S. Klimovskaya N. V. Amanova M. S. Zaynulina S. A. Selkov D. I. Sokolov
author_sort	V. A. Mikhaylova
title	EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
title_short	EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
title_full	EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
title_fullStr	EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
title_full_unstemmed	EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY
title_sort	expression of adhesion molecules on peripheral blood monocytes during pregnancy
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/1ef47a6792b541e28cace2539b7e2ec2
work_keys_str_mv	AT vamikhaylova expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT ysklimovskaya expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT nvamanova expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT mszaynulina expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT saselkov expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy AT disokolov expressionofadhesionmoleculesonperipheralbloodmonocytesduringpregnancy
_version_	1718422529242038272

EXPRESSION OF ADHESION MOLECULES ON PERIPHERAL BLOOD MONOCYTES DURING PREGNANCY

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