CCDC88B is required for pathogenesis of inflammatory bowel disease

Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease or ulce...

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Autores principales:	Nassima Fodil, Neda Moradin, Vicki Leung, Jean-Frederic Olivier, Irena Radovanovic, Thiviya Jeyakumar, Manuel Flores Molina, Ashley McFarquhar, Romain Cayrol, Dominique Bozec, Naglaa H. Shoukry, Michiaki Kubo, Julia Dimitrieva, Edouard Louis, Emilie Theatre, Stephanie Dahan, Yukihide Momozawa, Michel Georges, Garabet Yeretssian, Philippe Gros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1ef769869ff946e8995e6d2e8381e531
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spelling	oai:doaj.org-article:1ef769869ff946e8995e6d2e8381e5312021-12-02T17:06:23ZCCDC88B is required for pathogenesis of inflammatory bowel disease10.1038/s41467-017-01381-y2041-1723https://doaj.org/article/1ef769869ff946e8995e6d2e8381e5312017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01381-yhttps://doaj.org/toc/2041-1723Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease or ulcerative colitis, identifying that expression correlates with disease risk.Nassima FodilNeda MoradinVicki LeungJean-Frederic OlivierIrena RadovanovicThiviya JeyakumarManuel Flores MolinaAshley McFarquharRomain CayrolDominique BozecNaglaa H. ShoukryMichiaki KuboJulia DimitrievaEdouard LouisEmilie TheatreStephanie DahanYukihide MomozawaMichel GeorgesGarabet YeretssianPhilippe GrosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nassima Fodil Neda Moradin Vicki Leung Jean-Frederic Olivier Irena Radovanovic Thiviya Jeyakumar Manuel Flores Molina Ashley McFarquhar Romain Cayrol Dominique Bozec Naglaa H. Shoukry Michiaki Kubo Julia Dimitrieva Edouard Louis Emilie Theatre Stephanie Dahan Yukihide Momozawa Michel Georges Garabet Yeretssian Philippe Gros CCDC88B is required for pathogenesis of inflammatory bowel disease
description	Hook-related protein family member CCDC88b is encoded by a locus that has been associated with inflammatory bowel disease. Here the authors show that Ccdc88b inactivation in T cells prevents colitis in a transfer model, and detect high colonic levels of CCDC88b in patients with Crohn disease or ulcerative colitis, identifying that expression correlates with disease risk.
format	article
author	Nassima Fodil Neda Moradin Vicki Leung Jean-Frederic Olivier Irena Radovanovic Thiviya Jeyakumar Manuel Flores Molina Ashley McFarquhar Romain Cayrol Dominique Bozec Naglaa H. Shoukry Michiaki Kubo Julia Dimitrieva Edouard Louis Emilie Theatre Stephanie Dahan Yukihide Momozawa Michel Georges Garabet Yeretssian Philippe Gros
author_facet	Nassima Fodil Neda Moradin Vicki Leung Jean-Frederic Olivier Irena Radovanovic Thiviya Jeyakumar Manuel Flores Molina Ashley McFarquhar Romain Cayrol Dominique Bozec Naglaa H. Shoukry Michiaki Kubo Julia Dimitrieva Edouard Louis Emilie Theatre Stephanie Dahan Yukihide Momozawa Michel Georges Garabet Yeretssian Philippe Gros
author_sort	Nassima Fodil
title	CCDC88B is required for pathogenesis of inflammatory bowel disease
title_short	CCDC88B is required for pathogenesis of inflammatory bowel disease
title_full	CCDC88B is required for pathogenesis of inflammatory bowel disease
title_fullStr	CCDC88B is required for pathogenesis of inflammatory bowel disease
title_full_unstemmed	CCDC88B is required for pathogenesis of inflammatory bowel disease
title_sort	ccdc88b is required for pathogenesis of inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1ef769869ff946e8995e6d2e8381e531
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CCDC88B is required for pathogenesis of inflammatory bowel disease

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