Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis

Background and study aims Colon capsule endoscopy (CCE) is an alternative to conventional colonoscopy (CC) in specific clinical settings. High completion rates (CRs) and adequate cleanliness rates (ACRs) are fundamental quality parameters if CCE is to be widely implemented as a CC equivalent diagnos...

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Autores principales:	Thomas Bjoersum-Meyer, Karolina Skonieczna-Zydecka, Pablo Cortegoso Valdivia, Irene Stenfors, Ivan Lyutakov, Emanuele Rondonotti, Marco Pennazio, Wojciech Marlicz, Gunnar Baatrup, Anastasios Koulaouzidis, Ervin Toth
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/1ef9a89020d84052ba667e95a5165f50
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spelling	oai:doaj.org-article:1ef9a89020d84052ba667e95a5165f502021-11-13T00:00:31ZEfficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis2364-37222196-973610.1055/a-1529-5814https://doaj.org/article/1ef9a89020d84052ba667e95a5165f502021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1529-5814https://doaj.org/toc/2364-3722https://doaj.org/toc/2196-9736Background and study aims Colon capsule endoscopy (CCE) is an alternative to conventional colonoscopy (CC) in specific clinical settings. High completion rates (CRs) and adequate cleanliness rates (ACRs) are fundamental quality parameters if CCE is to be widely implemented as a CC equivalent diagnostic modality. We conducted a systematic review and meta-analysis to investigate the efficacy of different bowel preparations regimens on CR and ACR in CCE. Patients and methods We performed a systematic literature search in PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library. Data were independently extracted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The primary outcome measures (CR, ACR) were retrieved from the individual studies and pooled event rates were calculated. Results Thirty-four observational (OBS) studies (n = 3,789) and 12 randomized clinical trials (RCTs) (n = 1,214) comprising a total 5,003 patients were included. The overall CR was 0.798 (95 % CI, 0.764–0.828); the highest CRs were observed with sodium phosphate (NaP) + gastrografin booster (n = 2, CR = 0.931, 95 % CI, 0.820–0.976). The overall ACR was 0.768 (95 % CI, 0.735–0.797); the highest ACRs were observed with polyethylene glycol (PEG) + magnesium citrate (n = 4, ER = 0.953, 95 % CI, 0.896–0.979). Conclusions In the largest meta-analysis on CCE bowel preparation regimens, we found that both CRs and ACRs are suboptimal compared to the minimum recommended standards for CC. PEG laxative and NaP booster were the most commonly used but were not associated with higher CRs or ACRs. Well-designed studies on CCE should be performed to find the optimal preparation regimen.Thomas Bjoersum-MeyerKarolina Skonieczna-ZydeckaPablo Cortegoso ValdiviaIrene StenforsIvan LyutakovEmanuele RondonottiMarco PennazioWojciech MarliczGunnar BaatrupAnastasios KoulaouzidisErvin TothGeorg Thieme Verlag KGarticleDiseases of the digestive system. GastroenterologyRC799-869ENEndoscopy International Open, Vol 09, Iss 11, Pp E1658-E1673 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Thomas Bjoersum-Meyer Karolina Skonieczna-Zydecka Pablo Cortegoso Valdivia Irene Stenfors Ivan Lyutakov Emanuele Rondonotti Marco Pennazio Wojciech Marlicz Gunnar Baatrup Anastasios Koulaouzidis Ervin Toth Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
description	Background and study aims Colon capsule endoscopy (CCE) is an alternative to conventional colonoscopy (CC) in specific clinical settings. High completion rates (CRs) and adequate cleanliness rates (ACRs) are fundamental quality parameters if CCE is to be widely implemented as a CC equivalent diagnostic modality. We conducted a systematic review and meta-analysis to investigate the efficacy of different bowel preparations regimens on CR and ACR in CCE. Patients and methods We performed a systematic literature search in PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library. Data were independently extracted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The primary outcome measures (CR, ACR) were retrieved from the individual studies and pooled event rates were calculated. Results Thirty-four observational (OBS) studies (n = 3,789) and 12 randomized clinical trials (RCTs) (n = 1,214) comprising a total 5,003 patients were included. The overall CR was 0.798 (95 % CI, 0.764–0.828); the highest CRs were observed with sodium phosphate (NaP) + gastrografin booster (n = 2, CR = 0.931, 95 % CI, 0.820–0.976). The overall ACR was 0.768 (95 % CI, 0.735–0.797); the highest ACRs were observed with polyethylene glycol (PEG) + magnesium citrate (n = 4, ER = 0.953, 95 % CI, 0.896–0.979). Conclusions In the largest meta-analysis on CCE bowel preparation regimens, we found that both CRs and ACRs are suboptimal compared to the minimum recommended standards for CC. PEG laxative and NaP booster were the most commonly used but were not associated with higher CRs or ACRs. Well-designed studies on CCE should be performed to find the optimal preparation regimen.
format	article
author	Thomas Bjoersum-Meyer Karolina Skonieczna-Zydecka Pablo Cortegoso Valdivia Irene Stenfors Ivan Lyutakov Emanuele Rondonotti Marco Pennazio Wojciech Marlicz Gunnar Baatrup Anastasios Koulaouzidis Ervin Toth
author_facet	Thomas Bjoersum-Meyer Karolina Skonieczna-Zydecka Pablo Cortegoso Valdivia Irene Stenfors Ivan Lyutakov Emanuele Rondonotti Marco Pennazio Wojciech Marlicz Gunnar Baatrup Anastasios Koulaouzidis Ervin Toth
author_sort	Thomas Bjoersum-Meyer
title	Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
title_short	Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
title_full	Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
title_fullStr	Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
title_full_unstemmed	Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
title_sort	efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/1ef9a89020d84052ba667e95a5165f50
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Efficacy of bowel preparation regimens for colon capsule endoscopy: a systematic review and meta-analysis

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