Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste

Value-added phytochemicals from food by-products and waste materials have gained much interest and among them, dietary polyphenolic compounds with potential biological properties extend a promising sustainable approach. Oxyresveratrol (Oxy), a stilbenoid polyphenol, possesses great therapeutic poten...

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Autores principales:	Vidhya Prakash, Akshaya S Krishnan, Reshma Ramesh, Chinchu Bose, Girinath G. Pillai, Bipin G. Nair, Sanjay Pal
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polyphenols oxyresveratrol bioactivity probiotics value addition synbiotic Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/1efa4fd43ef94c9ba885a31c2a26bc6a
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spelling	oai:doaj.org-article:1efa4fd43ef94c9ba885a31c2a26bc6a2021-11-25T17:32:30ZSynergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste10.3390/foods101125482304-8158https://doaj.org/article/1efa4fd43ef94c9ba885a31c2a26bc6a2021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2548https://doaj.org/toc/2304-8158Value-added phytochemicals from food by-products and waste materials have gained much interest and among them, dietary polyphenolic compounds with potential biological properties extend a promising sustainable approach. Oxyresveratrol (Oxy), a stilbenoid polyphenol, possesses great therapeutic potential, though its pharmacokinetic issues need attention. A good source of oxyresveratrol was found in underutilized coconut shells and the synbiotic applications of the compound in combination with a potential probiotic isolate <i>Limosilactobacillus fermentum</i> ASBT-2 was investigated. The compound showed lower inhibitory effects on the strain with minimum inhibitory concentration (MIC) of 1000 µg/mL. Oxyresveratrol at sub-MIC concentrations (500 µg/mL and 250 µg/mL) enhanced the probiotic properties without exerting any inhibitory effects on the strain. The combination at sub- MIC concentration of the compound inhibited <i>Salmonella enterica</i> and in silico approaches were employed to elucidate the possible mode of action of oxy on the pathogen. Thus, the combination could target pathogens in the gut without exerting negative impacts on growth of beneficial strains. This approach could be a novel perspective to address the poor pharmacokinetic properties of the compound.Vidhya PrakashAkshaya S KrishnanReshma RameshChinchu BoseGirinath G. PillaiBipin G. NairSanjay PalMDPI AGarticlepolyphenolsoxyresveratrolbioactivityprobioticsvalue additionsynbioticChemical technologyTP1-1185ENFoods, Vol 10, Iss 2548, p 2548 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyphenols oxyresveratrol bioactivity probiotics value addition synbiotic Chemical technology TP1-1185
spellingShingle	polyphenols oxyresveratrol bioactivity probiotics value addition synbiotic Chemical technology TP1-1185 Vidhya Prakash Akshaya S Krishnan Reshma Ramesh Chinchu Bose Girinath G. Pillai Bipin G. Nair Sanjay Pal Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste
description	Value-added phytochemicals from food by-products and waste materials have gained much interest and among them, dietary polyphenolic compounds with potential biological properties extend a promising sustainable approach. Oxyresveratrol (Oxy), a stilbenoid polyphenol, possesses great therapeutic potential, though its pharmacokinetic issues need attention. A good source of oxyresveratrol was found in underutilized coconut shells and the synbiotic applications of the compound in combination with a potential probiotic isolate <i>Limosilactobacillus fermentum</i> ASBT-2 was investigated. The compound showed lower inhibitory effects on the strain with minimum inhibitory concentration (MIC) of 1000 µg/mL. Oxyresveratrol at sub-MIC concentrations (500 µg/mL and 250 µg/mL) enhanced the probiotic properties without exerting any inhibitory effects on the strain. The combination at sub- MIC concentration of the compound inhibited <i>Salmonella enterica</i> and in silico approaches were employed to elucidate the possible mode of action of oxy on the pathogen. Thus, the combination could target pathogens in the gut without exerting negative impacts on growth of beneficial strains. This approach could be a novel perspective to address the poor pharmacokinetic properties of the compound.
format	article
author	Vidhya Prakash Akshaya S Krishnan Reshma Ramesh Chinchu Bose Girinath G. Pillai Bipin G. Nair Sanjay Pal
author_facet	Vidhya Prakash Akshaya S Krishnan Reshma Ramesh Chinchu Bose Girinath G. Pillai Bipin G. Nair Sanjay Pal
author_sort	Vidhya Prakash
title	Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste
title_short	Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste
title_full	Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste
title_fullStr	Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste
title_full_unstemmed	Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste
title_sort	synergistic effects of <i>limosilactobacillus fermentum</i> asbt-2 with oxyresveratrol isolated from coconut shell waste
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1efa4fd43ef94c9ba885a31c2a26bc6a
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Synergistic Effects of <i>Limosilactobacillus fermentum</i> ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste

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