Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disease phenotypes when engrafted into an HD mouse...
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Nature Portfolio
2016
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oai:doaj.org-article:1efcf5bbea644ef3ac2340ad9aa2efda2021-12-02T16:56:46ZHuman glia can both induce and rescue aspects of disease phenotype in Huntington disease10.1038/ncomms117582041-1723https://doaj.org/article/1efcf5bbea644ef3ac2340ad9aa2efda2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11758https://doaj.org/toc/2041-1723The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disease phenotypes when engrafted into an HD mouse model.Abdellatif BenraissSu WangStephanie HerrlingerXiaojie LiDevin Chandler-MilitelloJoseph MauceriHayley B. BurmMichael TonerMikhail OsipovitchQiwu Jim XuFengfei DingFushun WangNing KangJian KangPaul C. CurtinDaniela BrunnerMartha S. WindremIgnacio Munoz-SanjuanMaiken NedergaardSteven A. GoldmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Abdellatif Benraiss Su Wang Stephanie Herrlinger Xiaojie Li Devin Chandler-Militello Joseph Mauceri Hayley B. Burm Michael Toner Mikhail Osipovitch Qiwu Jim Xu Fengfei Ding Fushun Wang Ning Kang Jian Kang Paul C. Curtin Daniela Brunner Martha S. Windrem Ignacio Munoz-Sanjuan Maiken Nedergaard Steven A. Goldman Human glia can both induce and rescue aspects of disease phenotype in Huntington disease |
| description |
The contribution of glia to Huntington's disease is unclear. The authors show that human glial progenitor cells (GPCs) expressing mutant huntingtin impair motor performance when engrafted into wild type mice, and wild type human GPCs ameliorate disease phenotypes when engrafted into an HD mouse model. |
| format |
article |
| author |
Abdellatif Benraiss Su Wang Stephanie Herrlinger Xiaojie Li Devin Chandler-Militello Joseph Mauceri Hayley B. Burm Michael Toner Mikhail Osipovitch Qiwu Jim Xu Fengfei Ding Fushun Wang Ning Kang Jian Kang Paul C. Curtin Daniela Brunner Martha S. Windrem Ignacio Munoz-Sanjuan Maiken Nedergaard Steven A. Goldman |
| author_facet |
Abdellatif Benraiss Su Wang Stephanie Herrlinger Xiaojie Li Devin Chandler-Militello Joseph Mauceri Hayley B. Burm Michael Toner Mikhail Osipovitch Qiwu Jim Xu Fengfei Ding Fushun Wang Ning Kang Jian Kang Paul C. Curtin Daniela Brunner Martha S. Windrem Ignacio Munoz-Sanjuan Maiken Nedergaard Steven A. Goldman |
| author_sort |
Abdellatif Benraiss |
| title |
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease |
| title_short |
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease |
| title_full |
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease |
| title_fullStr |
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease |
| title_full_unstemmed |
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease |
| title_sort |
human glia can both induce and rescue aspects of disease phenotype in huntington disease |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/1efcf5bbea644ef3ac2340ad9aa2efda |
| work_keys_str_mv |
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