A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis

A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis

Safe haemodialysis is essential for patients with acute kidney injury and renal failure. Here the authors present a DNA origami-based approach with high affinity and specificity to thrombin, inhibiting coagulation.

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Autores principales: Shuai Zhao, Run Tian, Jun Wu, Shaoli Liu, Yuanning Wang, Meng Wen, Yingxu Shang, Qing Liu, Yan Li, Ying Guo, Zhaoran Wang, Ting Wang, Yujing Zhao, Huiru Zhao, Hui Cao, Yu Su, Jiashu Sun, Qiao Jiang, Baoquan Ding
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1f01550336d84082a3d6c635dadf7846
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spelling oai:doaj.org-article:1f01550336d84082a3d6c635dadf78462021-12-02T15:22:39ZA DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis10.1038/s41467-020-20638-72041-1723https://doaj.org/article/1f01550336d84082a3d6c635dadf78462021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20638-7https://doaj.org/toc/2041-1723Safe haemodialysis is essential for patients with acute kidney injury and renal failure. Here the authors present a DNA origami-based approach with high affinity and specificity to thrombin, inhibiting coagulation.Shuai ZhaoRun TianJun WuShaoli LiuYuanning WangMeng WenYingxu ShangQing LiuYan LiYing GuoZhaoran WangTing WangYujing ZhaoHuiru ZhaoHui CaoYu SuJiashu SunQiao JiangBaoquan DingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shuai Zhao
Run Tian
Jun Wu
Shaoli Liu
Yuanning Wang
Meng Wen
Yingxu Shang
Qing Liu
Yan Li
Ying Guo
Zhaoran Wang
Ting Wang
Yujing Zhao
Huiru Zhao
Hui Cao
Yu Su
Jiashu Sun
Qiao Jiang
Baoquan Ding
A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
description Safe haemodialysis is essential for patients with acute kidney injury and renal failure. Here the authors present a DNA origami-based approach with high affinity and specificity to thrombin, inhibiting coagulation.
format article
author Shuai Zhao
Run Tian
Jun Wu
Shaoli Liu
Yuanning Wang
Meng Wen
Yingxu Shang
Qing Liu
Yan Li
Ying Guo
Zhaoran Wang
Ting Wang
Yujing Zhao
Huiru Zhao
Hui Cao
Yu Su
Jiashu Sun
Qiao Jiang
Baoquan Ding
author_facet Shuai Zhao
Run Tian
Jun Wu
Shaoli Liu
Yuanning Wang
Meng Wen
Yingxu Shang
Qing Liu
Yan Li
Ying Guo
Zhaoran Wang
Ting Wang
Yujing Zhao
Huiru Zhao
Hui Cao
Yu Su
Jiashu Sun
Qiao Jiang
Baoquan Ding
author_sort Shuai Zhao
title A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
title_short A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
title_full A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
title_fullStr A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
title_full_unstemmed A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
title_sort dna origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/1f01550336d84082a3d6c635dadf7846
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