Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion...

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Autores principales:	Amit Meir, Kevin Macé, Natalya Lukoyanova, David Chetrit, Manuela K. Hospenthal, Adam Redzej, Craig Roy, Gabriel Waksman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f01a2ef3e6d4f6f8a81da89f176c9c9
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spelling	oai:doaj.org-article:1f01a2ef3e6d4f6f8a81da89f176c9c92021-12-02T17:38:25ZMechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila10.1038/s41467-020-16681-z2041-1723https://doaj.org/article/1f01a2ef3e6d4f6f8a81da89f176c9c92020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16681-zhttps://doaj.org/toc/2041-1723A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion mechanisms.Amit MeirKevin MacéNatalya LukoyanovaDavid ChetritManuela K. HospenthalAdam RedzejCraig RoyGabriel WaksmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amit Meir Kevin Macé Natalya Lukoyanova David Chetrit Manuela K. Hospenthal Adam Redzej Craig Roy Gabriel Waksman Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
description	A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion mechanisms.
format	article
author	Amit Meir Kevin Macé Natalya Lukoyanova David Chetrit Manuela K. Hospenthal Adam Redzej Craig Roy Gabriel Waksman
author_facet	Amit Meir Kevin Macé Natalya Lukoyanova David Chetrit Manuela K. Hospenthal Adam Redzej Craig Roy Gabriel Waksman
author_sort	Amit Meir
title	Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
title_short	Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
title_full	Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
title_fullStr	Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
title_full_unstemmed	Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
title_sort	mechanism of effector capture and delivery by the type iv secretion system from legionella pneumophila
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f01a2ef3e6d4f6f8a81da89f176c9c9
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Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

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