Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion...

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Autores principales: Amit Meir, Kevin Macé, Natalya Lukoyanova, David Chetrit, Manuela K. Hospenthal, Adam Redzej, Craig Roy, Gabriel Waksman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1f01a2ef3e6d4f6f8a81da89f176c9c9
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