Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila
A membrane-embedded complex (called T4CC) is essential for injection of Legionella pneumophila effector proteins into human macrophages via a Type IV secretion system. Here, the authors purify and study the T4CC using functional and cryo-EM structural analyses, providing insights into the secretion...
Saved in:
Main Authors: | Amit Meir, Kevin Macé, Natalya Lukoyanova, David Chetrit, Manuela K. Hospenthal, Adam Redzej, Craig Roy, Gabriel Waksman |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/1f01a2ef3e6d4f6f8a81da89f176c9c9 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system
by: Amit Meir, et al.
Published: (2018) -
Legionella pneumophila
by: Ulloa F,María Teresa
Published: (2008) -
Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.
by: Xavier Charpentier, et al.
Published: (2009) -
An Indispensable Role for the MavE Effector of Legionella pneumophila in Lysosomal Evasion
by: Bethany Vaughn, et al.
Published: (2021) -
Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.
by: Mary F Fontana, et al.
Published: (2011)