3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

Studies examining human podocytopathies have utilised 2D cultured primary or immortalised podocyte cell lines. Here, the authors demonstrate that 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids retain an improved podocyte identity in vitro facilitating disease m...

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Autores principales:	Lorna J. Hale, Sara E. Howden, Belinda Phipson, Andrew Lonsdale, Pei X. Er, Irene Ghobrial, Salman Hosawi, Sean Wilson, Kynan T. Lawlor, Shahnaz Khan, Alicia Oshlack, Catherine Quinlan, Rachel Lennon, Melissa H. Little
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f054c26c4444f92a6c141194b7c9348
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spelling	oai:doaj.org-article:1f054c26c4444f92a6c141194b7c93482021-12-02T14:41:17Z3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening10.1038/s41467-018-07594-z2041-1723https://doaj.org/article/1f054c26c4444f92a6c141194b7c93482018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07594-zhttps://doaj.org/toc/2041-1723Studies examining human podocytopathies have utilised 2D cultured primary or immortalised podocyte cell lines. Here, the authors demonstrate that 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids retain an improved podocyte identity in vitro facilitating disease modelling and toxicity testing.Lorna J. HaleSara E. HowdenBelinda PhipsonAndrew LonsdalePei X. ErIrene GhobrialSalman HosawiSean WilsonKynan T. LawlorShahnaz KhanAlicia OshlackCatherine QuinlanRachel LennonMelissa H. LittleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorna J. Hale Sara E. Howden Belinda Phipson Andrew Lonsdale Pei X. Er Irene Ghobrial Salman Hosawi Sean Wilson Kynan T. Lawlor Shahnaz Khan Alicia Oshlack Catherine Quinlan Rachel Lennon Melissa H. Little 3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
description	Studies examining human podocytopathies have utilised 2D cultured primary or immortalised podocyte cell lines. Here, the authors demonstrate that 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids retain an improved podocyte identity in vitro facilitating disease modelling and toxicity testing.
format	article
author	Lorna J. Hale Sara E. Howden Belinda Phipson Andrew Lonsdale Pei X. Er Irene Ghobrial Salman Hosawi Sean Wilson Kynan T. Lawlor Shahnaz Khan Alicia Oshlack Catherine Quinlan Rachel Lennon Melissa H. Little
author_facet	Lorna J. Hale Sara E. Howden Belinda Phipson Andrew Lonsdale Pei X. Er Irene Ghobrial Salman Hosawi Sean Wilson Kynan T. Lawlor Shahnaz Khan Alicia Oshlack Catherine Quinlan Rachel Lennon Melissa H. Little
author_sort	Lorna J. Hale
title	3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
title_short	3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
title_full	3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
title_fullStr	3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
title_full_unstemmed	3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
title_sort	3d organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1f054c26c4444f92a6c141194b7c9348
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3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

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