Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.

Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome.

Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression is associated with poor prognosis. Inhibitors of FASN, such as orlistat, reportedly show antitumor effects against cancers that over-express FASN, making FASN a promising therapeutic target. However, large...

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Autores principales: Yukie Yoshii, Takako Furukawa, Nobuyuki Oyama, Yoko Hasegawa, Yasushi Kiyono, Ryuichi Nishii, Atsuo Waki, Atsushi B Tsuji, Chizuru Sogawa, Hidekatsu Wakizaka, Toshimitsu Fukumura, Hiroshi Yoshii, Yasuhisa Fujibayashi, Jason S Lewis, Tsuneo Saga
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1f05c698d43041ccb4452ef9e7cbc8d2
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