Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis

Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India. Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (...

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Autores principales:	Canna Jagdish Ghia, Gautam Sudhakar Rambhad
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1f0964be0374460e9ff119395947f676
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spelling	oai:doaj.org-article:1f0964be0374460e9ff119395947f6762021-11-30T23:34:07ZMeningococcal Disease Burden in India: A Systematic Review and Meta-Analysis1178-636110.1177/11786361211053344https://doaj.org/article/1f0964be0374460e9ff119395947f6762021-11-01T00:00:00Zhttps://doi.org/10.1177/11786361211053344https://doaj.org/toc/1178-6361Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India. Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively. Results: The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance. Conclusion: The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.Canna Jagdish GhiaGautam Sudhakar RambhadSAGE PublishingarticleMicrobiologyQR1-502ENMicrobiology Insights, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Canna Jagdish Ghia Gautam Sudhakar Rambhad Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis
description	Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India. Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively. Results: The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance. Conclusion: The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.
format	article
author	Canna Jagdish Ghia Gautam Sudhakar Rambhad
author_facet	Canna Jagdish Ghia Gautam Sudhakar Rambhad
author_sort	Canna Jagdish Ghia
title	Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis
title_short	Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis
title_full	Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis
title_fullStr	Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis
title_full_unstemmed	Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis
title_sort	meningococcal disease burden in india: a systematic review and meta-analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/1f0964be0374460e9ff119395947f676
work_keys_str_mv	AT cannajagdishghia meningococcaldiseaseburdeninindiaasystematicreviewandmetaanalysis AT gautamsudhakarrambhad meningococcaldiseaseburdeninindiaasystematicreviewandmetaanalysis
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Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis

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