Transformation of stimulus correlations by the retina.
Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simu...
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2013
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oai:doaj.org-article:1f1439fc53704e978d04af935e03258d2021-11-18T05:53:20ZTransformation of stimulus correlations by the retina.1553-734X1553-735810.1371/journal.pcbi.1003344https://doaj.org/article/1f1439fc53704e978d04af935e03258d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24339756/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at the ganglion cell input, largely explained the pattern of pairwise correlations across stimuli where receptive field measurements were possible.Kristina D SimmonsJason S PrenticeGašper TkačikJan HomannHeather K YeeStephanie E PalmerPhilip C NelsonVijay BalasubramanianPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 9, Iss 12, p e1003344 (2013) |
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DOAJ |
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DOAJ |
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| topic |
Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Kristina D Simmons Jason S Prentice Gašper Tkačik Jan Homann Heather K Yee Stephanie E Palmer Philip C Nelson Vijay Balasubramanian Transformation of stimulus correlations by the retina. |
| description |
Redundancies and correlations in the responses of sensory neurons may seem to waste neural resources, but they can also carry cues about structured stimuli and may help the brain to correct for response errors. To investigate the effect of stimulus structure on redundancy in retina, we measured simultaneous responses from populations of retinal ganglion cells presented with natural and artificial stimuli that varied greatly in correlation structure; these stimuli and recordings are publicly available online. Responding to spatio-temporally structured stimuli such as natural movies, pairs of ganglion cells were modestly more correlated than in response to white noise checkerboards, but they were much less correlated than predicted by a non-adapting functional model of retinal response. Meanwhile, responding to stimuli with purely spatial correlations, pairs of ganglion cells showed increased correlations consistent with a static, non-adapting receptive field and nonlinearity. We found that in response to spatio-temporally correlated stimuli, ganglion cells had faster temporal kernels and tended to have stronger surrounds. These properties of individual cells, along with gain changes that opposed changes in effective contrast at the ganglion cell input, largely explained the pattern of pairwise correlations across stimuli where receptive field measurements were possible. |
| format |
article |
| author |
Kristina D Simmons Jason S Prentice Gašper Tkačik Jan Homann Heather K Yee Stephanie E Palmer Philip C Nelson Vijay Balasubramanian |
| author_facet |
Kristina D Simmons Jason S Prentice Gašper Tkačik Jan Homann Heather K Yee Stephanie E Palmer Philip C Nelson Vijay Balasubramanian |
| author_sort |
Kristina D Simmons |
| title |
Transformation of stimulus correlations by the retina. |
| title_short |
Transformation of stimulus correlations by the retina. |
| title_full |
Transformation of stimulus correlations by the retina. |
| title_fullStr |
Transformation of stimulus correlations by the retina. |
| title_full_unstemmed |
Transformation of stimulus correlations by the retina. |
| title_sort |
transformation of stimulus correlations by the retina. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/1f1439fc53704e978d04af935e03258d |
| work_keys_str_mv |
AT kristinadsimmons transformationofstimuluscorrelationsbytheretina AT jasonsprentice transformationofstimuluscorrelationsbytheretina AT gaspertkacik transformationofstimuluscorrelationsbytheretina AT janhomann transformationofstimuluscorrelationsbytheretina AT heatherkyee transformationofstimuluscorrelationsbytheretina AT stephanieepalmer transformationofstimuluscorrelationsbytheretina AT philipcnelson transformationofstimuluscorrelationsbytheretina AT vijaybalasubramanian transformationofstimuluscorrelationsbytheretina |
| _version_ |
1718424652785647616 |