Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community

Abstract Background Early evaluations of healthcare professional (HCP) COVID-19 risk occurred during insufficient personal protective equipment and disproportionate testing, contributing to perceptions of high patient-care related HCP risk. We evaluated HCP COVID-19 seropositivity after accounting f...

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Autores principales:	Shruti K. Gohil, Kathleen A. Quan, Keith M. Madey, Suzanne King-Adelsohn, Tom Tjoa, Delia Tifrea, Bridgit O. Crews, Edwin S. Monuki, Saahir Khan, Sebastian D. Schubl, Cassiana E. Bittencourt, Neil Detweiler, Wayne Chang, Lynn Willis, Usme Khusbu, Antonella Saturno, Sherif A. Rezk, Cesar Figueroa, Aarti Jain, Rafael Assis, Philip Felgner, Robert Edwards, Lanny Hsieh, Donald Forthal, William C. Wilson, Michael J. Stamos, Susan S. Huang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	COVID-19 seroprevalence Healthcare worker COVID-19 exposure COVID-19 outbreaks Severe acute respiratory syndrome coronavirus-2 Healthcare professional COVID-19 exposure Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/1f157951ed82497887ebb7727d5bcb75
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spelling	oai:doaj.org-article:1f157951ed82497887ebb7727d5bcb752021-11-28T12:37:43ZInfection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community10.1186/s13756-021-01031-52047-2994https://doaj.org/article/1f157951ed82497887ebb7727d5bcb752021-11-01T00:00:00Zhttps://doi.org/10.1186/s13756-021-01031-5https://doaj.org/toc/2047-2994Abstract Background Early evaluations of healthcare professional (HCP) COVID-19 risk occurred during insufficient personal protective equipment and disproportionate testing, contributing to perceptions of high patient-care related HCP risk. We evaluated HCP COVID-19 seropositivity after accounting for community factors and coworker outbreaks. Methods Prior to universal masking, we conducted a single-center retrospective cohort plus cross-sectional study. All HCP (1) seen by Occupational Health for COVID-like symptoms (regardless of test result) or assigned to (2) dedicated COVID-19 units, (3) units with a COVID-19 HCP outbreak, or (4) control units from 01/01/2020 to 04/15/2020 were offered serologic testing by an FDA-authorized assay plus a research assay against 67 respiratory viruses, including 11 SARS-CoV-2 antigens. Multivariable models assessed the association of demographics, job role, comorbidities, care of a COVID-19 patient, and geocoded socioeconomic status with positive serology. Results Of 654 participants, 87 (13.3%) were seropositive; among these 60.8% (N = 52) had never cared for a COVID-19 patient. Being male (OR 1.79, CI 1.05–3.04, p = 0.03), working in a unit with a HCP-outbreak unit (OR 2.21, CI 1.28–3.81, p < 0.01), living in a community with low owner-occupied housing (OR = 1.63, CI = 1.00–2.64, p = 0.05), and ethnically Latino (OR 2.10, CI 1.12–3.96, p = 0.02) were positively-associated with COVID-19 seropositivity, while working in dedicated COVID-19 units was negatively-associated (OR 0.53, CI = 0.30–0.94, p = 0.03). The research assay identified 25 additional seropositive individuals (78 [12%] vs. 53 [8%], p < 0.01). Conclusions Prior to universal masking, HCP COVID-19 risk was dominated by workplace and community exposures while working in a dedicated COVID-19 unit was protective, suggesting that infection prevention protocols prevent patient-to-HCP transmission. Article summary Prior to universal masking, HCP COVID-19 risk was dominated by workplace and community exposures while working in a dedicated COVID-19 unit was protective, suggesting that infection prevention protocols prevent patient-to-HCP transmission.Shruti K. GohilKathleen A. QuanKeith M. MadeySuzanne King-AdelsohnTom TjoaDelia TifreaBridgit O. CrewsEdwin S. MonukiSaahir KhanSebastian D. SchublCassiana E. BittencourtNeil DetweilerWayne ChangLynn WillisUsme KhusbuAntonella SaturnoSherif A. RezkCesar FigueroaAarti JainRafael AssisPhilip FelgnerRobert EdwardsLanny HsiehDonald ForthalWilliam C. WilsonMichael J. StamosSusan S. HuangBMCarticleCOVID-19 seroprevalenceHealthcare worker COVID-19 exposureCOVID-19 outbreaksSevere acute respiratory syndrome coronavirus-2Healthcare professional COVID-19 exposureInfectious and parasitic diseasesRC109-216ENAntimicrobial Resistance and Infection Control, Vol 10, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 seroprevalence Healthcare worker COVID-19 exposure COVID-19 outbreaks Severe acute respiratory syndrome coronavirus-2 Healthcare professional COVID-19 exposure Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 seroprevalence Healthcare worker COVID-19 exposure COVID-19 outbreaks Severe acute respiratory syndrome coronavirus-2 Healthcare professional COVID-19 exposure Infectious and parasitic diseases RC109-216 Shruti K. Gohil Kathleen A. Quan Keith M. Madey Suzanne King-Adelsohn Tom Tjoa Delia Tifrea Bridgit O. Crews Edwin S. Monuki Saahir Khan Sebastian D. Schubl Cassiana E. Bittencourt Neil Detweiler Wayne Chang Lynn Willis Usme Khusbu Antonella Saturno Sherif A. Rezk Cesar Figueroa Aarti Jain Rafael Assis Philip Felgner Robert Edwards Lanny Hsieh Donald Forthal William C. Wilson Michael J. Stamos Susan S. Huang Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
description	Abstract Background Early evaluations of healthcare professional (HCP) COVID-19 risk occurred during insufficient personal protective equipment and disproportionate testing, contributing to perceptions of high patient-care related HCP risk. We evaluated HCP COVID-19 seropositivity after accounting for community factors and coworker outbreaks. Methods Prior to universal masking, we conducted a single-center retrospective cohort plus cross-sectional study. All HCP (1) seen by Occupational Health for COVID-like symptoms (regardless of test result) or assigned to (2) dedicated COVID-19 units, (3) units with a COVID-19 HCP outbreak, or (4) control units from 01/01/2020 to 04/15/2020 were offered serologic testing by an FDA-authorized assay plus a research assay against 67 respiratory viruses, including 11 SARS-CoV-2 antigens. Multivariable models assessed the association of demographics, job role, comorbidities, care of a COVID-19 patient, and geocoded socioeconomic status with positive serology. Results Of 654 participants, 87 (13.3%) were seropositive; among these 60.8% (N = 52) had never cared for a COVID-19 patient. Being male (OR 1.79, CI 1.05–3.04, p = 0.03), working in a unit with a HCP-outbreak unit (OR 2.21, CI 1.28–3.81, p < 0.01), living in a community with low owner-occupied housing (OR = 1.63, CI = 1.00–2.64, p = 0.05), and ethnically Latino (OR 2.10, CI 1.12–3.96, p = 0.02) were positively-associated with COVID-19 seropositivity, while working in dedicated COVID-19 units was negatively-associated (OR 0.53, CI = 0.30–0.94, p = 0.03). The research assay identified 25 additional seropositive individuals (78 [12%] vs. 53 [8%], p < 0.01). Conclusions Prior to universal masking, HCP COVID-19 risk was dominated by workplace and community exposures while working in a dedicated COVID-19 unit was protective, suggesting that infection prevention protocols prevent patient-to-HCP transmission. Article summary Prior to universal masking, HCP COVID-19 risk was dominated by workplace and community exposures while working in a dedicated COVID-19 unit was protective, suggesting that infection prevention protocols prevent patient-to-HCP transmission.
format	article
author	Shruti K. Gohil Kathleen A. Quan Keith M. Madey Suzanne King-Adelsohn Tom Tjoa Delia Tifrea Bridgit O. Crews Edwin S. Monuki Saahir Khan Sebastian D. Schubl Cassiana E. Bittencourt Neil Detweiler Wayne Chang Lynn Willis Usme Khusbu Antonella Saturno Sherif A. Rezk Cesar Figueroa Aarti Jain Rafael Assis Philip Felgner Robert Edwards Lanny Hsieh Donald Forthal William C. Wilson Michael J. Stamos Susan S. Huang
author_facet	Shruti K. Gohil Kathleen A. Quan Keith M. Madey Suzanne King-Adelsohn Tom Tjoa Delia Tifrea Bridgit O. Crews Edwin S. Monuki Saahir Khan Sebastian D. Schubl Cassiana E. Bittencourt Neil Detweiler Wayne Chang Lynn Willis Usme Khusbu Antonella Saturno Sherif A. Rezk Cesar Figueroa Aarti Jain Rafael Assis Philip Felgner Robert Edwards Lanny Hsieh Donald Forthal William C. Wilson Michael J. Stamos Susan S. Huang
author_sort	Shruti K. Gohil
title	Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
title_short	Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
title_full	Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
title_fullStr	Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
title_full_unstemmed	Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community
title_sort	infection prevention strategies are highly protective in covid-19 units while main risks to healthcare professionals come from coworkers and the community
publisher	BMC
publishDate	2021
url	https://doaj.org/article/1f157951ed82497887ebb7727d5bcb75
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_version_	1718407878589546496

Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community

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