Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions

Stereotactic biopsy of posterior fossa lesions is often regarded as hazardous due to the critical structures in that area. Therefore, the aim of the study was to evaluate the diagnostic accuracy and safety of infratentorial stereotactic biopsy of brainstem or cerebellar lesions and its associations...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jacek Furtak, Paulina Śledzińska, Marek G. Bebyn, Tadeusz Szylberg, Stanisław Krajewski, Marcin Birski, Marek Harat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brainstem tumors infratentorial approach molecular analyses procedural complications stereotactic biopsy <i>Toxoplasma gondii</i> Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1f173c93bcfa4a5fabb8d94e4b3c3e21
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1f173c93bcfa4a5fabb8d94e4b3c3e21
record_format	dspace
spelling	oai:doaj.org-article:1f173c93bcfa4a5fabb8d94e4b3c3e212021-11-25T16:57:09ZInfratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions10.3390/brainsci111114322076-3425https://doaj.org/article/1f173c93bcfa4a5fabb8d94e4b3c3e212021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1432https://doaj.org/toc/2076-3425Stereotactic biopsy of posterior fossa lesions is often regarded as hazardous due to the critical structures in that area. Therefore, the aim of the study was to evaluate the diagnostic accuracy and safety of infratentorial stereotactic biopsy of brainstem or cerebellar lesions and its associations with other clinical, laboratory, and radiological parameters. From January 2000 to May 2021, 190 infratentorial stereotactic biopsies of posterior fossa tumors, including 108 biopsies of brainstem lesions, were performed. Moreover, 63 supratentorial biopsies of cerebral peduncle lesions were analyzed to compare the safety and efficacy of both approaches. Additionally, the presence of antibodies against <i>Toxoplasma gondii</i> and Epstein–Barr Virus (EBV) were documented in 67 and 66 patients, respectively, and magnetic resonance imaging (MRI) scans were evaluated in 114 patients. Only 4% of patients had minor complications and 1.5% had major complications, including one patient who died from intracranial bleeding. Nine (4.7%) biopsies were non-diagnostic. Isocitrate dehydrogenase 1 (<i>IDH1</i>) mutation, 1p/19q codeletion, and O6-methylguanine-DNA methyltransferase (<i>MGMT</i>) promoter methylation status were assessed in 29 patients, and were non-diagnostic in only 3 (10.3%) cases. Patients with high-grade gliomas (HGG) were more frequently seropositive for <i>T. gondii</i> than individuals with low-grade gliomas (LGG; <i>p</i> < 0.001). A total of 27% of HGG and 41% of LGG were non-enhancing on MRI. The infratentorial approach is generally safe and reliable for biopsy of brainstem and cerebellar lesions. In our study, the safety and efficacy of supratentorial biopsy of the cerebral peduncle and infratentorial biopsy of lesions below the cerebral peduncle were comparably high. Moreover, patients with HGG were more frequently seropositive for <i>T. gondii</i> than patients with LGG, and the relationship between toxoplasmosis and gliomagenesis requires further investigation.Jacek FurtakPaulina ŚledzińskaMarek G. BebynTadeusz SzylbergStanisław KrajewskiMarcin BirskiMarek HaratMDPI AGarticlebrainstem tumorsinfratentorial approachmolecular analysesprocedural complicationsstereotactic biopsy<i>Toxoplasma gondii</i>Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1432, p 1432 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brainstem tumors infratentorial approach molecular analyses procedural complications stereotactic biopsy <i>Toxoplasma gondii</i> Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	brainstem tumors infratentorial approach molecular analyses procedural complications stereotactic biopsy <i>Toxoplasma gondii</i> Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jacek Furtak Paulina Śledzińska Marek G. Bebyn Tadeusz Szylberg Stanisław Krajewski Marcin Birski Marek Harat Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
description	Stereotactic biopsy of posterior fossa lesions is often regarded as hazardous due to the critical structures in that area. Therefore, the aim of the study was to evaluate the diagnostic accuracy and safety of infratentorial stereotactic biopsy of brainstem or cerebellar lesions and its associations with other clinical, laboratory, and radiological parameters. From January 2000 to May 2021, 190 infratentorial stereotactic biopsies of posterior fossa tumors, including 108 biopsies of brainstem lesions, were performed. Moreover, 63 supratentorial biopsies of cerebral peduncle lesions were analyzed to compare the safety and efficacy of both approaches. Additionally, the presence of antibodies against <i>Toxoplasma gondii</i> and Epstein–Barr Virus (EBV) were documented in 67 and 66 patients, respectively, and magnetic resonance imaging (MRI) scans were evaluated in 114 patients. Only 4% of patients had minor complications and 1.5% had major complications, including one patient who died from intracranial bleeding. Nine (4.7%) biopsies were non-diagnostic. Isocitrate dehydrogenase 1 (<i>IDH1</i>) mutation, 1p/19q codeletion, and O6-methylguanine-DNA methyltransferase (<i>MGMT</i>) promoter methylation status were assessed in 29 patients, and were non-diagnostic in only 3 (10.3%) cases. Patients with high-grade gliomas (HGG) were more frequently seropositive for <i>T. gondii</i> than individuals with low-grade gliomas (LGG; <i>p</i> < 0.001). A total of 27% of HGG and 41% of LGG were non-enhancing on MRI. The infratentorial approach is generally safe and reliable for biopsy of brainstem and cerebellar lesions. In our study, the safety and efficacy of supratentorial biopsy of the cerebral peduncle and infratentorial biopsy of lesions below the cerebral peduncle were comparably high. Moreover, patients with HGG were more frequently seropositive for <i>T. gondii</i> than patients with LGG, and the relationship between toxoplasmosis and gliomagenesis requires further investigation.
format	article
author	Jacek Furtak Paulina Śledzińska Marek G. Bebyn Tadeusz Szylberg Stanisław Krajewski Marcin Birski Marek Harat
author_facet	Jacek Furtak Paulina Śledzińska Marek G. Bebyn Tadeusz Szylberg Stanisław Krajewski Marcin Birski Marek Harat
author_sort	Jacek Furtak
title	Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
title_short	Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
title_full	Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
title_fullStr	Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
title_full_unstemmed	Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
title_sort	infratentorial stereotactic biopsy of brainstem and cerebellar lesions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1f173c93bcfa4a5fabb8d94e4b3c3e21
work_keys_str_mv	AT jacekfurtak infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions AT paulinasledzinska infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions AT marekgbebyn infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions AT tadeuszszylberg infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions AT stanisławkrajewski infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions AT marcinbirski infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions AT marekharat infratentorialstereotacticbiopsyofbrainstemandcerebellarlesions
_version_	1718412823836491776

Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions

Ejemplares similares