TGFβ signalling acts as a molecular brake of myoblast fusion

Fusion of myoblasts is essential for muscle development and repair, but the molecular mechanism underlying this process remains unclear. Here, the authors show, using chicken embryos as a model, that TGFβ signalling inhibits fusion via a receptor complementation mechanism, and indicate the involveme...

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Autores principales:	Julie Melendez, Daniel Sieiro, David Salgado, Valérie Morin, Marie-Julie Dejardin, Chan Zhou, Alan C. Mullen, Christophe Marcelle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f196d50dffa44f2b977707d6b639b8c
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spelling	oai:doaj.org-article:1f196d50dffa44f2b977707d6b639b8c2021-12-02T14:33:40ZTGFβ signalling acts as a molecular brake of myoblast fusion10.1038/s41467-020-20290-12041-1723https://doaj.org/article/1f196d50dffa44f2b977707d6b639b8c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20290-1https://doaj.org/toc/2041-1723Fusion of myoblasts is essential for muscle development and repair, but the molecular mechanism underlying this process remains unclear. Here, the authors show, using chicken embryos as a model, that TGFβ signalling inhibits fusion via a receptor complementation mechanism, and indicate the involvement of endocytic degradation of activated receptors in modulation of this process.Julie MelendezDaniel SieiroDavid SalgadoValérie MorinMarie-Julie DejardinChan ZhouAlan C. MullenChristophe MarcelleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julie Melendez Daniel Sieiro David Salgado Valérie Morin Marie-Julie Dejardin Chan Zhou Alan C. Mullen Christophe Marcelle TGFβ signalling acts as a molecular brake of myoblast fusion
description	Fusion of myoblasts is essential for muscle development and repair, but the molecular mechanism underlying this process remains unclear. Here, the authors show, using chicken embryos as a model, that TGFβ signalling inhibits fusion via a receptor complementation mechanism, and indicate the involvement of endocytic degradation of activated receptors in modulation of this process.
format	article
author	Julie Melendez Daniel Sieiro David Salgado Valérie Morin Marie-Julie Dejardin Chan Zhou Alan C. Mullen Christophe Marcelle
author_facet	Julie Melendez Daniel Sieiro David Salgado Valérie Morin Marie-Julie Dejardin Chan Zhou Alan C. Mullen Christophe Marcelle
author_sort	Julie Melendez
title	TGFβ signalling acts as a molecular brake of myoblast fusion
title_short	TGFβ signalling acts as a molecular brake of myoblast fusion
title_full	TGFβ signalling acts as a molecular brake of myoblast fusion
title_fullStr	TGFβ signalling acts as a molecular brake of myoblast fusion
title_full_unstemmed	TGFβ signalling acts as a molecular brake of myoblast fusion
title_sort	tgfβ signalling acts as a molecular brake of myoblast fusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f196d50dffa44f2b977707d6b639b8c
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TGFβ signalling acts as a molecular brake of myoblast fusion

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