Role of stem cells in fertility preservation: current insights

Maxime Vermeulen,1 Maria-Grazia Giudice,1,2 Federico Del Vento,1 Christine Wyns1,21Gynecology-Andrology Research Unit, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, 1200, Belgium; 2Department of Gynecology-Andrology, Cliniqu...

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Autores principales:	Vermeulen M, Giudice MG, Del Vento F, Wyns C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Transplantation fertility restoration mesenchymal stem cells germline stem cells spermatogonial stem cells in vitro maturation Cytology QH573-671
Acceso en línea:	https://doaj.org/article/1f19c65bb1c84ade8be5872484d1b5f6
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spelling	oai:doaj.org-article:1f19c65bb1c84ade8be5872484d1b5f62021-12-02T03:05:33ZRole of stem cells in fertility preservation: current insights1178-6957https://doaj.org/article/1f19c65bb1c84ade8be5872484d1b5f62019-08-01T00:00:00Zhttps://www.dovepress.com/role-of-stem-cells-in-fertility-preservation-current-insights-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957Maxime Vermeulen,1 Maria-Grazia Giudice,1,2 Federico Del Vento,1 Christine Wyns1,21Gynecology-Andrology Research Unit, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, 1200, Belgium; 2Department of Gynecology-Andrology, Cliniques Universitaires Saint-Luc, Brussels 1200, BelgiumAbstract: While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of healthy babies after autotransplantation and is performed in an increasing number of centers. For prepubertal boys who do not produce gametes ready for fertilization, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells may be proposed as an experimental strategy with the aim of restoring fertility. Based on achievements in nonhuman primates, autotransplantation of ITT or testicular cell suspensions appears promising to restore fertility of young cancer survivors. So far, whether in two- or three-dimensional culture systems, in vitro maturation of immature male and female gonadal cells or tissue has not demonstrated a capacity to produce safe gametes for ART. Recently, primordial germ cells have been generated from embryonic and induced pluripotent stem cells, but further investigations regarding efficiency and safety are needed. Transplantation of mesenchymal stem cells to improve the vascularization of gonadal tissue grafts, increase the colonization of transplanted cells, and restore the damaged somatic compartment could overcome the current limitations encountered with transplantation.Keywords: transplantation, fertility restoration, mesenchymal stem cells, germ-line stem cells, spermatogonial stem cells, in vitro maturation  Vermeulen MGiudice MGDel Vento FWyns CDove Medical PressarticleTransplantationfertility restorationmesenchymal stem cellsgermline stem cellsspermatogonial stem cellsin vitro maturationCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 12, Pp 27-48 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transplantation fertility restoration mesenchymal stem cells germline stem cells spermatogonial stem cells in vitro maturation Cytology QH573-671
spellingShingle	Transplantation fertility restoration mesenchymal stem cells germline stem cells spermatogonial stem cells in vitro maturation Cytology QH573-671 Vermeulen M Giudice MG Del Vento F Wyns C Role of stem cells in fertility preservation: current insights
description	Maxime Vermeulen,1 Maria-Grazia Giudice,1,2 Federico Del Vento,1 Christine Wyns1,21Gynecology-Andrology Research Unit, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, 1200, Belgium; 2Department of Gynecology-Andrology, Cliniques Universitaires Saint-Luc, Brussels 1200, BelgiumAbstract: While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of healthy babies after autotransplantation and is performed in an increasing number of centers. For prepubertal boys who do not produce gametes ready for fertilization, cryopreservation of immature testicular tissue (ITT) containing spermatogonial stem cells may be proposed as an experimental strategy with the aim of restoring fertility. Based on achievements in nonhuman primates, autotransplantation of ITT or testicular cell suspensions appears promising to restore fertility of young cancer survivors. So far, whether in two- or three-dimensional culture systems, in vitro maturation of immature male and female gonadal cells or tissue has not demonstrated a capacity to produce safe gametes for ART. Recently, primordial germ cells have been generated from embryonic and induced pluripotent stem cells, but further investigations regarding efficiency and safety are needed. Transplantation of mesenchymal stem cells to improve the vascularization of gonadal tissue grafts, increase the colonization of transplanted cells, and restore the damaged somatic compartment could overcome the current limitations encountered with transplantation.Keywords: transplantation, fertility restoration, mesenchymal stem cells, germ-line stem cells, spermatogonial stem cells, in vitro maturation
format	article
author	Vermeulen M Giudice MG Del Vento F Wyns C
author_facet	Vermeulen M Giudice MG Del Vento F Wyns C
author_sort	Vermeulen M
title	Role of stem cells in fertility preservation: current insights
title_short	Role of stem cells in fertility preservation: current insights
title_full	Role of stem cells in fertility preservation: current insights
title_fullStr	Role of stem cells in fertility preservation: current insights
title_full_unstemmed	Role of stem cells in fertility preservation: current insights
title_sort	role of stem cells in fertility preservation: current insights
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/1f19c65bb1c84ade8be5872484d1b5f6
work_keys_str_mv	AT vermeulenm roleofstemcellsinfertilitypreservationcurrentinsights AT giudicemg roleofstemcellsinfertilitypreservationcurrentinsights AT delventof roleofstemcellsinfertilitypreservationcurrentinsights AT wynsc roleofstemcellsinfertilitypreservationcurrentinsights
_version_	1718401967336718336

Role of stem cells in fertility preservation: current insights

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