The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma

Noriko Himori,1 Maki Inoue Yanagimachi,1 Kazuko Omodaka,1,2 Yukihiro Shiga,1 Satoru Tsuda,1 Hiroshi Kunikata,1,3 Toru Nakazawa1– 4 1Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Department of Ophthalmic Imaging and Information Analytics, Tohoku...

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Autores principales:	Himori N, Inoue Yanagimachi M, Omodaka K, Shiga Y, Tsuda S, Kunikata H, Nakazawa T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	oxidative stress supplement glaucoma 8-ohdg Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1f20354f97d546908132ebb0e55468d2
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spelling	oai:doaj.org-article:1f20354f97d546908132ebb0e55468d22021-12-02T18:05:05ZThe Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma1177-5483https://doaj.org/article/1f20354f97d546908132ebb0e55468d22021-06-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-dietary-antioxidant-supplementation-in-patients-with-gla-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Noriko Himori,1 Maki Inoue Yanagimachi,1 Kazuko Omodaka,1,2 Yukihiro Shiga,1 Satoru Tsuda,1 Hiroshi Kunikata,1,3 Toru Nakazawa1– 4 1Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Japan; 3Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan; 4Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanCorrespondence: Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho Aoba-ku, Sendai, Miyagi, 980-8574, JapanTel +81-22-717-7294Fax +81-22-717-7298Email ntoru@oph.med.tohoku.ac.jpPurpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on markers of oxidative stress in patients with glaucoma.Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett’s test.Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (P < 0.001, P < 0.01, P < 0.01, P < 0.01), and BAP was significantly elevated at weeks 8 and 12 (P = 0.03, P = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (P =0.03, P = 0.04), while BAP was not significantly elevated.Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.Keywords: oxidative stress, supplement, glaucoma, 8-OHdGHimori NInoue Yanagimachi MOmodaka KShiga YTsuda SKunikata HNakazawa TDove Medical Pressarticleoxidative stresssupplementglaucoma8-ohdgOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 2293-2300 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxidative stress supplement glaucoma 8-ohdg Ophthalmology RE1-994
spellingShingle	oxidative stress supplement glaucoma 8-ohdg Ophthalmology RE1-994 Himori N Inoue Yanagimachi M Omodaka K Shiga Y Tsuda S Kunikata H Nakazawa T The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
description	Noriko Himori,1 Maki Inoue Yanagimachi,1 Kazuko Omodaka,1,2 Yukihiro Shiga,1 Satoru Tsuda,1 Hiroshi Kunikata,1,3 Toru Nakazawa1– 4 1Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan; 2Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Japan; 3Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan; 4Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, JapanCorrespondence: Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho Aoba-ku, Sendai, Miyagi, 980-8574, JapanTel +81-22-717-7294Fax +81-22-717-7298Email ntoru@oph.med.tohoku.ac.jpPurpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and Tamarindus indica) on markers of oxidative stress in patients with glaucoma.Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett’s test.Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (P < 0.001, P < 0.01, P < 0.01, P < 0.01), and BAP was significantly elevated at weeks 8 and 12 (P = 0.03, P = 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (P =0.03, P = 0.04), while BAP was not significantly elevated.Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.Keywords: oxidative stress, supplement, glaucoma, 8-OHdG
format	article
author	Himori N Inoue Yanagimachi M Omodaka K Shiga Y Tsuda S Kunikata H Nakazawa T
author_facet	Himori N Inoue Yanagimachi M Omodaka K Shiga Y Tsuda S Kunikata H Nakazawa T
author_sort	Himori N
title	The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
title_short	The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
title_full	The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
title_fullStr	The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
title_full_unstemmed	The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma
title_sort	effect of dietary antioxidant supplementation in patients with glaucoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1f20354f97d546908132ebb0e55468d2
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The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma

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