Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory fe...

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Autores principales:	Roni Allaoui, Caroline Bergenfelz, Sofie Mohlin, Catharina Hagerling, Kiarash Salari, Zena Werb, Robin L. Anderson, Stephen P. Ethier, Karin Jirström, Sven Påhlman, Daniel Bexell, Balázs Tahin, Martin E. Johansson, Christer Larsson, Karin Leandersson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f209c930311471d8fa8c3d468ef2dc6
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spelling	oai:doaj.org-article:1f209c930311471d8fa8c3d468ef2dc62021-12-02T16:49:27ZCancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers10.1038/ncomms130502041-1723https://doaj.org/article/1f209c930311471d8fa8c3d468ef2dc62016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13050https://doaj.org/toc/2041-1723A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory feedback loop.Roni AllaouiCaroline BergenfelzSofie MohlinCatharina HagerlingKiarash SalariZena WerbRobin L. AndersonStephen P. EthierKarin JirströmSven PåhlmanDaniel BexellBalázs TahinMartin E. JohanssonChrister LarssonKarin LeanderssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roni Allaoui Caroline Bergenfelz Sofie Mohlin Catharina Hagerling Kiarash Salari Zena Werb Robin L. Anderson Stephen P. Ethier Karin Jirström Sven Påhlman Daniel Bexell Balázs Tahin Martin E. Johansson Christer Larsson Karin Leandersson Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
description	A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory feedback loop.
format	article
author	Roni Allaoui Caroline Bergenfelz Sofie Mohlin Catharina Hagerling Kiarash Salari Zena Werb Robin L. Anderson Stephen P. Ethier Karin Jirström Sven Påhlman Daniel Bexell Balázs Tahin Martin E. Johansson Christer Larsson Karin Leandersson
author_facet	Roni Allaoui Caroline Bergenfelz Sofie Mohlin Catharina Hagerling Kiarash Salari Zena Werb Robin L. Anderson Stephen P. Ethier Karin Jirström Sven Påhlman Daniel Bexell Balázs Tahin Martin E. Johansson Christer Larsson Karin Leandersson
author_sort	Roni Allaoui
title	Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
title_short	Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
title_full	Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
title_fullStr	Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
title_full_unstemmed	Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
title_sort	cancer-associated fibroblast-secreted cxcl16 attracts monocytes to promote stroma activation in triple-negative breast cancers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1f209c930311471d8fa8c3d468ef2dc6
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Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

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