Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers

A reactive tumour stroma is associated with poor prognosis. Here, the authors show that in patients with triple negative breast cancer resident monocytes activate cancer-associated fibroblasts and induce production of CXCL16, which acts as a monocyte chemoattractant, resulting in an amplificatory fe...

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Autores principales: Roni Allaoui, Caroline Bergenfelz, Sofie Mohlin, Catharina Hagerling, Kiarash Salari, Zena Werb, Robin L. Anderson, Stephen P. Ethier, Karin Jirström, Sven Påhlman, Daniel Bexell, Balázs Tahin, Martin E. Johansson, Christer Larsson, Karin Leandersson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/1f209c930311471d8fa8c3d468ef2dc6
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