Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites

Abstract Attempts have been made to reduce the total scan time in multi-dimensional J-resolved spectroscopic imaging (JRESI) using an echo-planar (EP) readout gradient, but acquisition duration remains a limitation for routine clinical use in the brain. We present here a significant acceleration ach...

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Autores principales:	Manoj K. Sarma, Rajakumar Nagarajan, Zohaib Iqbal, Paul M. Macey, M. Albert Thomas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f2117b390e54134a58396b93d4d8d9c
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spelling	oai:doaj.org-article:1f2117b390e54134a58396b93d4d8d9c2021-12-02T16:07:02ZEcho-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites10.1038/s41598-017-03121-02045-2322https://doaj.org/article/1f2117b390e54134a58396b93d4d8d9c2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03121-0https://doaj.org/toc/2045-2322Abstract Attempts have been made to reduce the total scan time in multi-dimensional J-resolved spectroscopic imaging (JRESI) using an echo-planar (EP) readout gradient, but acquisition duration remains a limitation for routine clinical use in the brain. We present here a significant acceleration achieved with a 4D EP-JRESI sequence that collects dual phase encoded lines within a single repetition time (TR) using two bipolar read-out trains. The performance and reliability of this novel 4D sequence, called Multi-Echo based Echo-Planar J-resolved Spectroscopic Imaging (ME-EP-JRESI), was evaluated in 10 healthy controls and a brain phantom using a 3 T MRI/MRS scanner. The prior knowledge fitting (ProFit) algorithm, with a new simulated basis set consisting of macromolecules and lipids apart from metabolites of interest, was used for quantitation. Both phantom and in-vivo data demonstrated that localization and spatial/spectral profiles of metabolites from the ME-EP-JRESI sequence were in good agreement with that of the EP-JRESI sequence. Both in the occipital and temporal lobe, metabolites with higher physiological concentrations including Glx (Glu+Gln), tNAA (NAA+NAAG), mI all had coefficient of variations between 9–25%. In summary, we have implemented, validated and tested the ME-EP-JRESI sequence, demonstrating that multi-echo acquisition can successfully reduce the total scan duration for EP-JRESI sequences.Manoj K. SarmaRajakumar NagarajanZohaib IqbalPaul M. MaceyM. Albert ThomasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manoj K. Sarma Rajakumar Nagarajan Zohaib Iqbal Paul M. Macey M. Albert Thomas Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites
description	Abstract Attempts have been made to reduce the total scan time in multi-dimensional J-resolved spectroscopic imaging (JRESI) using an echo-planar (EP) readout gradient, but acquisition duration remains a limitation for routine clinical use in the brain. We present here a significant acceleration achieved with a 4D EP-JRESI sequence that collects dual phase encoded lines within a single repetition time (TR) using two bipolar read-out trains. The performance and reliability of this novel 4D sequence, called Multi-Echo based Echo-Planar J-resolved Spectroscopic Imaging (ME-EP-JRESI), was evaluated in 10 healthy controls and a brain phantom using a 3 T MRI/MRS scanner. The prior knowledge fitting (ProFit) algorithm, with a new simulated basis set consisting of macromolecules and lipids apart from metabolites of interest, was used for quantitation. Both phantom and in-vivo data demonstrated that localization and spatial/spectral profiles of metabolites from the ME-EP-JRESI sequence were in good agreement with that of the EP-JRESI sequence. Both in the occipital and temporal lobe, metabolites with higher physiological concentrations including Glx (Glu+Gln), tNAA (NAA+NAAG), mI all had coefficient of variations between 9–25%. In summary, we have implemented, validated and tested the ME-EP-JRESI sequence, demonstrating that multi-echo acquisition can successfully reduce the total scan duration for EP-JRESI sequences.
format	article
author	Manoj K. Sarma Rajakumar Nagarajan Zohaib Iqbal Paul M. Macey M. Albert Thomas
author_facet	Manoj K. Sarma Rajakumar Nagarajan Zohaib Iqbal Paul M. Macey M. Albert Thomas
author_sort	Manoj K. Sarma
title	Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites
title_short	Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites
title_full	Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites
title_fullStr	Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites
title_full_unstemmed	Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites
title_sort	echo-planar j-resolved spectroscopic imaging using dual read-outs: implementation and quantitation of human brain metabolites
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1f2117b390e54134a58396b93d4d8d9c
work_keys_str_mv	AT manojksarma echoplanarjresolvedspectroscopicimagingusingdualreadoutsimplementationandquantitationofhumanbrainmetabolites AT rajakumarnagarajan echoplanarjresolvedspectroscopicimagingusingdualreadoutsimplementationandquantitationofhumanbrainmetabolites AT zohaibiqbal echoplanarjresolvedspectroscopicimagingusingdualreadoutsimplementationandquantitationofhumanbrainmetabolites AT paulmmacey echoplanarjresolvedspectroscopicimagingusingdualreadoutsimplementationandquantitationofhumanbrainmetabolites AT malbertthomas echoplanarjresolvedspectroscopicimagingusingdualreadoutsimplementationandquantitationofhumanbrainmetabolites
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Echo-Planar J-resolved Spectroscopic Imaging using Dual Read-outs: Implementation and Quantitation of Human Brain Metabolites

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