Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure

Abstract The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined dat...

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Autores principales:	Gijs Geleijnse, RuRu Chun-Ju Chiang, Melle Sieswerda, Melinda Schuurman, K. C. Lee, Johan van Soest, Andre Dekker, Wen-Chung Lee, Xander A. A. M. Verbeek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f211f44a3204968a69737189b7fcdf1
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spelling	oai:doaj.org-article:1f211f44a3204968a69737189b7fcdf12021-12-02T12:33:53ZPrognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure10.1038/s41598-020-77476-22045-2322https://doaj.org/article/1f211f44a3204968a69737189b7fcdf12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77476-2https://doaj.org/toc/2045-2322Abstract The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633‬ patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.Gijs GeleijnseRuRu Chun-Ju ChiangMelle SieswerdaMelinda SchuurmanK. C. LeeJohan van SoestAndre DekkerWen-Chung LeeXander A. A. M. VerbeekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gijs Geleijnse RuRu Chun-Ju Chiang Melle Sieswerda Melinda Schuurman K. C. Lee Johan van Soest Andre Dekker Wen-Chung Lee Xander A. A. M. Verbeek Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
description	Abstract The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633‬ patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.
format	article
author	Gijs Geleijnse RuRu Chun-Ju Chiang Melle Sieswerda Melinda Schuurman K. C. Lee Johan van Soest Andre Dekker Wen-Chung Lee Xander A. A. M. Verbeek
author_facet	Gijs Geleijnse RuRu Chun-Ju Chiang Melle Sieswerda Melinda Schuurman K. C. Lee Johan van Soest Andre Dekker Wen-Chung Lee Xander A. A. M. Verbeek
author_sort	Gijs Geleijnse
title	Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_short	Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_full	Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_fullStr	Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_full_unstemmed	Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_sort	prognostic factors analysis for oral cavity cancer survival in the netherlands and taiwan using a privacy-preserving federated infrastructure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f211f44a3204968a69737189b7fcdf1
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Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure

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