Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure

Abstract The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined dat...

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Autores principales: Gijs Geleijnse, RuRu Chun-Ju Chiang, Melle Sieswerda, Melinda Schuurman, K. C. Lee, Johan van Soest, Andre Dekker, Wen-Chung Lee, Xander A. A. M. Verbeek
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1f211f44a3204968a69737189b7fcdf1
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spelling oai:doaj.org-article:1f211f44a3204968a69737189b7fcdf12021-12-02T12:33:53ZPrognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure10.1038/s41598-020-77476-22045-2322https://doaj.org/article/1f211f44a3204968a69737189b7fcdf12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77476-2https://doaj.org/toc/2045-2322Abstract The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633‬ patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.Gijs GeleijnseRuRu Chun-Ju ChiangMelle SieswerdaMelinda SchuurmanK. C. LeeJohan van SoestAndre DekkerWen-Chung LeeXander A. A. M. VerbeekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Gijs Geleijnse
RuRu Chun-Ju Chiang
Melle Sieswerda
Melinda Schuurman
K. C. Lee
Johan van Soest
Andre Dekker
Wen-Chung Lee
Xander A. A. M. Verbeek
Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
description Abstract The difference in incidence of oral cavity cancer (OCC) between Taiwan and the Netherlands is striking. Different risk factors and treatment expertise may result in survival differences between the two countries. However due to regulatory restrictions, patient-level analyses of combined data from the Netherlands and Taiwan are infeasible. We implemented a software infrastructure for federated analyses on data from multiple organisations. We included 41,633‬ patients with single-tumour OCC between 2004 and 2016, undergoing surgery, from the Taiwan Cancer Registry and Netherlands Cancer Registry. Federated Cox Proportional Hazard was used to analyse associations between patient and tumour characteristics, country, treatment and hospital volume with survival. Five factors showed differential effects on survival of OCC patients in the Netherlands and Taiwan: age at diagnosis, stage, grade, treatment and hospital volume. The risk of death for OCC patients younger than 60 years, with advanced stage, higher grade or receiving adjuvant therapy after surgery was lower in the Netherlands than in Taiwan; but patients older than 70 years, with early stage, lower grade and receiving surgery alone in the Netherlands were at higher risk of death than those in Taiwan. The mortality risk of OCC in Taiwanese patients treated in hospitals with higher hospital volume (≥ 50 surgeries per year) was lower than in Dutch patients. We conducted analyses without exchanging patient-level information, overcoming barriers for sharing privacy sensitive information. The outcomes of patients treated in the Netherlands and Taiwan were slightly different after controlling for other prognostic factors.
format article
author Gijs Geleijnse
RuRu Chun-Ju Chiang
Melle Sieswerda
Melinda Schuurman
K. C. Lee
Johan van Soest
Andre Dekker
Wen-Chung Lee
Xander A. A. M. Verbeek
author_facet Gijs Geleijnse
RuRu Chun-Ju Chiang
Melle Sieswerda
Melinda Schuurman
K. C. Lee
Johan van Soest
Andre Dekker
Wen-Chung Lee
Xander A. A. M. Verbeek
author_sort Gijs Geleijnse
title Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_short Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_full Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_fullStr Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_full_unstemmed Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure
title_sort prognostic factors analysis for oral cavity cancer survival in the netherlands and taiwan using a privacy-preserving federated infrastructure
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1f211f44a3204968a69737189b7fcdf1
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