Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients

Background. It is still unclear whether COVID-19 convalescent kidney transplant recipients (KTR) and hemodialysis (HD) patients can develop anti-SARS-CoV-2 adaptive immunity. The aim was to characterize and compare the immune response to the virus in HD patients and KTR. Methods. The study included...

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Autores principales:	Dorota Kamińska, Hanna Augustyniak-Bartosik, Katarzyna Kościelska-Kasprzak, Marcelina Żabińska, Dorota Bartoszek, Paweł Poznański, Magdalena Kuriata-Kordek, Mariusz Kusztal, Oktawia Mazanowska, Magdalena Krajewska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	COVID-19 SARS-CoV-2 hemodialysis kidney transplantation humoral immunity antibodies Medicine R
Acceso en línea:	https://doaj.org/article/1f227085b9804b219a9b26340ccf31e3
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spelling	oai:doaj.org-article:1f227085b9804b219a9b26340ccf31e32021-11-11T17:30:22ZComparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients10.3390/jcm102148332077-0383https://doaj.org/article/1f227085b9804b219a9b26340ccf31e32021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4833https://doaj.org/toc/2077-0383Background. It is still unclear whether COVID-19 convalescent kidney transplant recipients (KTR) and hemodialysis (HD) patients can develop anti-SARS-CoV-2 adaptive immunity. The aim was to characterize and compare the immune response to the virus in HD patients and KTR. Methods. The study included 26 HD patients and 54 KTR—both convalescent (14 HD, 25 KTR) and unexposed. The immune response was assessed by determining the anti-SARS-CoV-2 antibodies in serum and specific T cell response via the interferon-gamma release assay (IGRA). Moreover, blood-morphology-derived parameters, immune cell phenotypes, and acute phase reactants were evaluated. Results. KRT and HD convalescents presented similar serum levels of anti-SARS-CoV-2 IgG and IgA. A negative correlation occurred between IgG and time after the infection was observed. There was a strong relationship between the prevalence of anti-SARS-CoV-2 cellular and humoral responses in both groups. Convalescent IGRA response was significantly higher in HD patients compared to KTR. Conclusions. HD patients and KTR develop humoral and cellular responses after COVID-19. The antibodies levels are similar in both groups of patients. SARS-CoV-2-reactive T cell response is stronger in HD patients compared to KTR. The SARS-CoV-2-specific IgG level decreases with time while IgA and a cellular response are maintained. IGRA proved to be a valuable test for the assessment of specific cellular immunity in immunocompromised HD patients and KTR.Dorota KamińskaHanna Augustyniak-BartosikKatarzyna Kościelska-KasprzakMarcelina ŻabińskaDorota BartoszekPaweł PoznańskiMagdalena Kuriata-KordekMariusz KusztalOktawia MazanowskaMagdalena KrajewskaMDPI AGarticleCOVID-19SARS-CoV-2hemodialysiskidney transplantationhumoral immunityantibodiesMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4833, p 4833 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 hemodialysis kidney transplantation humoral immunity antibodies Medicine R
spellingShingle	COVID-19 SARS-CoV-2 hemodialysis kidney transplantation humoral immunity antibodies Medicine R Dorota Kamińska Hanna Augustyniak-Bartosik Katarzyna Kościelska-Kasprzak Marcelina Żabińska Dorota Bartoszek Paweł Poznański Magdalena Kuriata-Kordek Mariusz Kusztal Oktawia Mazanowska Magdalena Krajewska Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients
description	Background. It is still unclear whether COVID-19 convalescent kidney transplant recipients (KTR) and hemodialysis (HD) patients can develop anti-SARS-CoV-2 adaptive immunity. The aim was to characterize and compare the immune response to the virus in HD patients and KTR. Methods. The study included 26 HD patients and 54 KTR—both convalescent (14 HD, 25 KTR) and unexposed. The immune response was assessed by determining the anti-SARS-CoV-2 antibodies in serum and specific T cell response via the interferon-gamma release assay (IGRA). Moreover, blood-morphology-derived parameters, immune cell phenotypes, and acute phase reactants were evaluated. Results. KRT and HD convalescents presented similar serum levels of anti-SARS-CoV-2 IgG and IgA. A negative correlation occurred between IgG and time after the infection was observed. There was a strong relationship between the prevalence of anti-SARS-CoV-2 cellular and humoral responses in both groups. Convalescent IGRA response was significantly higher in HD patients compared to KTR. Conclusions. HD patients and KTR develop humoral and cellular responses after COVID-19. The antibodies levels are similar in both groups of patients. SARS-CoV-2-reactive T cell response is stronger in HD patients compared to KTR. The SARS-CoV-2-specific IgG level decreases with time while IgA and a cellular response are maintained. IGRA proved to be a valuable test for the assessment of specific cellular immunity in immunocompromised HD patients and KTR.
format	article
author	Dorota Kamińska Hanna Augustyniak-Bartosik Katarzyna Kościelska-Kasprzak Marcelina Żabińska Dorota Bartoszek Paweł Poznański Magdalena Kuriata-Kordek Mariusz Kusztal Oktawia Mazanowska Magdalena Krajewska
author_facet	Dorota Kamińska Hanna Augustyniak-Bartosik Katarzyna Kościelska-Kasprzak Marcelina Żabińska Dorota Bartoszek Paweł Poznański Magdalena Kuriata-Kordek Mariusz Kusztal Oktawia Mazanowska Magdalena Krajewska
author_sort	Dorota Kamińska
title	Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients
title_short	Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients
title_full	Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients
title_fullStr	Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients
title_full_unstemmed	Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients
title_sort	comparing humoral and cellular adaptive immunity during convalescent phase of covid-19 in hemodialysis patients and kidney transplant recipients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1f227085b9804b219a9b26340ccf31e3
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Comparing Humoral and Cellular Adaptive Immunity during Convalescent Phase of COVID-19 in Hemodialysis Patients and Kidney Transplant Recipients

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