Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions

Abstract Auditory verbal hallucinations (AVH, ‘hearing voices’) are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they are perceptual in nature, specifically that they reflect spontaneous abnormal neuronal activity in...

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Autores principales:	Paola Fuentes-Claramonte, Joan Soler-Vidal, Pilar Salgado-Pineda, María Ángeles García-León, Nuria Ramiro, Aniol Santo-Angles, María Llanos Torres, Josep Tristany, Amalia Guerrero-Pedraza, Josep Munuera, Salvador Sarró, Raymond Salvador, Wolfram Hinzen, Peter J. McKenna, Edith Pomarol-Clotet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f23c6d6bf39491eb2b5b98c660ffa8a
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spelling	oai:doaj.org-article:1f23c6d6bf39491eb2b5b98c660ffa8a2021-12-02T15:15:05ZAuditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions10.1038/s41598-021-98269-12045-2322https://doaj.org/article/1f23c6d6bf39491eb2b5b98c660ffa8a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98269-1https://doaj.org/toc/2045-2322Abstract Auditory verbal hallucinations (AVH, ‘hearing voices’) are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they are perceptual in nature, specifically that they reflect spontaneous abnormal neuronal activity in the auditory cortex, perhaps with additional ‘top down’ cognitive influences. Functional imaging studies employing the symptom capture technique—where activity when patients experience AVH is compared to times when they do not—have had mixed findings as to whether the auditory cortex is activated. Here, using a novel variant of the symptom capture technique, we show that the experience of AVH does not induce auditory cortex activation, even while real speech does, something that effectively rules out all theories that propose a perceptual component to AVH. Instead, we find that the experience of AVH activates language regions and/or regions that are engaged during verbal short-term memory.Paola Fuentes-ClaramonteJoan Soler-VidalPilar Salgado-PinedaMaría Ángeles García-LeónNuria RamiroAniol Santo-AnglesMaría Llanos TorresJosep TristanyAmalia Guerrero-PedrazaJosep MunueraSalvador SarróRaymond SalvadorWolfram HinzenPeter J. McKennaEdith Pomarol-ClotetNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paola Fuentes-Claramonte Joan Soler-Vidal Pilar Salgado-Pineda María Ángeles García-León Nuria Ramiro Aniol Santo-Angles María Llanos Torres Josep Tristany Amalia Guerrero-Pedraza Josep Munuera Salvador Sarró Raymond Salvador Wolfram Hinzen Peter J. McKenna Edith Pomarol-Clotet Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
description	Abstract Auditory verbal hallucinations (AVH, ‘hearing voices’) are an important symptom of schizophrenia but their biological basis is not well understood. One longstanding approach proposes that they are perceptual in nature, specifically that they reflect spontaneous abnormal neuronal activity in the auditory cortex, perhaps with additional ‘top down’ cognitive influences. Functional imaging studies employing the symptom capture technique—where activity when patients experience AVH is compared to times when they do not—have had mixed findings as to whether the auditory cortex is activated. Here, using a novel variant of the symptom capture technique, we show that the experience of AVH does not induce auditory cortex activation, even while real speech does, something that effectively rules out all theories that propose a perceptual component to AVH. Instead, we find that the experience of AVH activates language regions and/or regions that are engaged during verbal short-term memory.
format	article
author	Paola Fuentes-Claramonte Joan Soler-Vidal Pilar Salgado-Pineda María Ángeles García-León Nuria Ramiro Aniol Santo-Angles María Llanos Torres Josep Tristany Amalia Guerrero-Pedraza Josep Munuera Salvador Sarró Raymond Salvador Wolfram Hinzen Peter J. McKenna Edith Pomarol-Clotet
author_facet	Paola Fuentes-Claramonte Joan Soler-Vidal Pilar Salgado-Pineda María Ángeles García-León Nuria Ramiro Aniol Santo-Angles María Llanos Torres Josep Tristany Amalia Guerrero-Pedraza Josep Munuera Salvador Sarró Raymond Salvador Wolfram Hinzen Peter J. McKenna Edith Pomarol-Clotet
author_sort	Paola Fuentes-Claramonte
title	Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
title_short	Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
title_full	Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
title_fullStr	Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
title_full_unstemmed	Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
title_sort	auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f23c6d6bf39491eb2b5b98c660ffa8a
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Auditory hallucinations activate language and verbal short-term memory, but not auditory, brain regions

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