Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study

Yilin Feng,1 Jemin Park,1 Yunshu Zhou,1 Stephen T Armenti,1 David C Musch,1,2 Shahzad I Mian1 1Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA; 2Department of Epidemiology, University of Michigan, Ann Arbor, MI, USACorrespondence: Shahz...

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Autores principales:	Feng Y, Park J, Zhou Y, Armenti ST, Musch DC, Mian SI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	covid-19 conjunctivitis ocular manifestations ocular surface Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1f241b2a253e44f69a129b48a2cf7bf3
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spelling	oai:doaj.org-article:1f241b2a253e44f69a129b48a2cf7bf32021-12-02T14:21:25ZOcular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study1177-5483https://doaj.org/article/1f241b2a253e44f69a129b48a2cf7bf32021-04-01T00:00:00Zhttps://www.dovepress.com/ocular-manifestations-of-hospitalized-covid-19-patients-in-a-tertiary--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Yilin Feng,1 Jemin Park,1 Yunshu Zhou,1 Stephen T Armenti,1 David C Musch,1,2 Shahzad I Mian1 1Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA; 2Department of Epidemiology, University of Michigan, Ann Arbor, MI, USACorrespondence: Shahzad I MianProfessor of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, 1000 Wall St, Ann Arbor, MI, 48105, USATel +1 734-763-5904Email smian@med.umich.eduPurpose: Studies have identified a wide range of ocular signs and symptoms in coronavirus disease 2019 (COVID-19) patients; however, these studies were often conducted outside of the United States. We aim to investigate the ocular manifestations of hospitalized COVID-19 patients at a tertiary care medical center in the United States.Patients and Methods: A retrospective, cross-sectional study was conducted on individuals aged 18 and over who were hospitalized for COVID-19 between March 10, 2020 and April 13, 2020. The electronic health record was reviewed for all patients, and a follow-up phone survey was conducted on patients who were discharged home. Data on patient history, physical exam, laboratory results, and hospital disposition were collected and analyzed.Results: A total of 400 patients were included. The mean patient age was 61.7 years (SD 15.5) and 233 (58.3%) were males. Ocular signs and symptoms were noted in 38 (9.5%) patients. The most common ocular abnormality was conjunctival injection, followed by vision changes and ocular irritation. Among the 38 patients, 30 (79.0%) developed ocular involvement prior to day 30 of onset of their COVID symptoms. Univariate analysis showed that age, gender, ocular history, fever, mechanical ventilation, and increasing inflammatory markers were not significantly associated with the presence or development of ocular symptoms.Conclusion: In this study, 9.5% of hospitalized COVID-19 patients exhibited ocular signs and symptoms. Factors associated with severe systemic COVID-19 disease were not associated with developing ocular abnormalities. The rate of ocular manifestations of COVID-19 should not be ignored, and thus physicians should routinely evaluate for ocular involvement in hospitalized COVID-19 patients.Keywords: COVID-19, conjunctivitis, ocular manifestations, ocular surfaceFeng YPark JZhou YArmenti STMusch DCMian SIDove Medical Pressarticlecovid-19conjunctivitisocular manifestationsocular surfaceOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1551-1556 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 conjunctivitis ocular manifestations ocular surface Ophthalmology RE1-994
spellingShingle	covid-19 conjunctivitis ocular manifestations ocular surface Ophthalmology RE1-994 Feng Y Park J Zhou Y Armenti ST Musch DC Mian SI Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
description	Yilin Feng,1 Jemin Park,1 Yunshu Zhou,1 Stephen T Armenti,1 David C Musch,1,2 Shahzad I Mian1 1Department of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, Ann Arbor, MI, USA; 2Department of Epidemiology, University of Michigan, Ann Arbor, MI, USACorrespondence: Shahzad I MianProfessor of Ophthalmology and Visual Sciences, University of Michigan, Kellogg Eye Center, 1000 Wall St, Ann Arbor, MI, 48105, USATel +1 734-763-5904Email smian@med.umich.eduPurpose: Studies have identified a wide range of ocular signs and symptoms in coronavirus disease 2019 (COVID-19) patients; however, these studies were often conducted outside of the United States. We aim to investigate the ocular manifestations of hospitalized COVID-19 patients at a tertiary care medical center in the United States.Patients and Methods: A retrospective, cross-sectional study was conducted on individuals aged 18 and over who were hospitalized for COVID-19 between March 10, 2020 and April 13, 2020. The electronic health record was reviewed for all patients, and a follow-up phone survey was conducted on patients who were discharged home. Data on patient history, physical exam, laboratory results, and hospital disposition were collected and analyzed.Results: A total of 400 patients were included. The mean patient age was 61.7 years (SD 15.5) and 233 (58.3%) were males. Ocular signs and symptoms were noted in 38 (9.5%) patients. The most common ocular abnormality was conjunctival injection, followed by vision changes and ocular irritation. Among the 38 patients, 30 (79.0%) developed ocular involvement prior to day 30 of onset of their COVID symptoms. Univariate analysis showed that age, gender, ocular history, fever, mechanical ventilation, and increasing inflammatory markers were not significantly associated with the presence or development of ocular symptoms.Conclusion: In this study, 9.5% of hospitalized COVID-19 patients exhibited ocular signs and symptoms. Factors associated with severe systemic COVID-19 disease were not associated with developing ocular abnormalities. The rate of ocular manifestations of COVID-19 should not be ignored, and thus physicians should routinely evaluate for ocular involvement in hospitalized COVID-19 patients.Keywords: COVID-19, conjunctivitis, ocular manifestations, ocular surface
format	article
author	Feng Y Park J Zhou Y Armenti ST Musch DC Mian SI
author_facet	Feng Y Park J Zhou Y Armenti ST Musch DC Mian SI
author_sort	Feng Y
title	Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
title_short	Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
title_full	Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
title_fullStr	Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
title_full_unstemmed	Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
title_sort	ocular manifestations of hospitalized covid-19 patients in a tertiary care academic medical center in the united states: a cross-sectional study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1f241b2a253e44f69a129b48a2cf7bf3
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Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study

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