Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction

The application of polygenic risk scores to individual-level disease susceptibility is challenging, as risk is evaluated at a group-level. Here, the authors describe a machine learning method, Mondrian Cross-Conformal Prediction, that reports disease status conditional probability value at the indiv...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiangming Sun, Yunpeng Wang, Lasse Folkersen, Yan Borné, Inge Amlien, Alfonso Buil, Marju Orho-Melander, Anders D. Børglum, David M. Hougaard, Regeneron Genetics Center, Olle Melander, Gunnar Engström, Thomas Werge, Kasper Lage
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f27829d10184dee8d91f723afe0978e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1f27829d10184dee8d91f723afe0978e
record_format	dspace
spelling	oai:doaj.org-article:1f27829d10184dee8d91f723afe0978e2021-12-02T17:19:40ZTranslating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction10.1038/s41467-021-25014-72041-1723https://doaj.org/article/1f27829d10184dee8d91f723afe0978e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25014-7https://doaj.org/toc/2041-1723The application of polygenic risk scores to individual-level disease susceptibility is challenging, as risk is evaluated at a group-level. Here, the authors describe a machine learning method, Mondrian Cross-Conformal Prediction, that reports disease status conditional probability value at the individual level.Jiangming SunYunpeng WangLasse FolkersenYan BornéInge AmlienAlfonso BuilMarju Orho-MelanderAnders D. BørglumDavid M. HougaardRegeneron Genetics CenterOlle MelanderGunnar EngströmThomas WergeKasper LageNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiangming Sun Yunpeng Wang Lasse Folkersen Yan Borné Inge Amlien Alfonso Buil Marju Orho-Melander Anders D. Børglum David M. Hougaard Regeneron Genetics Center Olle Melander Gunnar Engström Thomas Werge Kasper Lage Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
description	The application of polygenic risk scores to individual-level disease susceptibility is challenging, as risk is evaluated at a group-level. Here, the authors describe a machine learning method, Mondrian Cross-Conformal Prediction, that reports disease status conditional probability value at the individual level.
format	article
author	Jiangming Sun Yunpeng Wang Lasse Folkersen Yan Borné Inge Amlien Alfonso Buil Marju Orho-Melander Anders D. Børglum David M. Hougaard Regeneron Genetics Center Olle Melander Gunnar Engström Thomas Werge Kasper Lage
author_facet	Jiangming Sun Yunpeng Wang Lasse Folkersen Yan Borné Inge Amlien Alfonso Buil Marju Orho-Melander Anders D. Børglum David M. Hougaard Regeneron Genetics Center Olle Melander Gunnar Engström Thomas Werge Kasper Lage
author_sort	Jiangming Sun
title	Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
title_short	Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
title_full	Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
title_fullStr	Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
title_full_unstemmed	Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
title_sort	translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f27829d10184dee8d91f723afe0978e
work_keys_str_mv	AT jiangmingsun translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT yunpengwang translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT lassefolkersen translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT yanborne translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT ingeamlien translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT alfonsobuil translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT marjuorhomelander translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT andersdbørglum translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT davidmhougaard translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT regenerongeneticscenter translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT ollemelander translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT gunnarengstrom translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT thomaswerge translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction AT kasperlage translatingpolygenicriskscoresforclinicalusebyestimatingtheconfidenceboundsofriskprediction
_version_	1718381012989247488

Translating polygenic risk scores for clinical use by estimating the confidence bounds of risk prediction

Ejemplares similares