Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge. Here, the authors show that phosphoglycerate dehydrogenase, a key enzyme in the serine synthesis pathway, drives sorafenib resistance.

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Autores principales:	Lai Wei, Derek Lee, Cheuk-Ting Law, Misty Shuo Zhang, Jialing Shen, Don Wai-Ching Chin, Allen Zhang, Felice Ho-Ching Tsang, Ceci Lok-Sze Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f27ce98d13a42cd9355ac519e4b7c2f
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spelling	oai:doaj.org-article:1f27ce98d13a42cd9355ac519e4b7c2f2021-12-02T14:39:16ZGenome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC10.1038/s41467-019-12606-72041-1723https://doaj.org/article/1f27ce98d13a42cd9355ac519e4b7c2f2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12606-7https://doaj.org/toc/2041-1723Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge. Here, the authors show that phosphoglycerate dehydrogenase, a key enzyme in the serine synthesis pathway, drives sorafenib resistance.Lai WeiDerek LeeCheuk-Ting LawMisty Shuo ZhangJialing ShenDon Wai-Ching ChinAllen ZhangFelice Ho-Ching TsangCeci Lok-Sze WongIrene Oi-Lin NgCarmen Chak-Lui WongChun-Ming WongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lai Wei Derek Lee Cheuk-Ting Law Misty Shuo Zhang Jialing Shen Don Wai-Ching Chin Allen Zhang Felice Ho-Ching Tsang Ceci Lok-Sze Wong Irene Oi-Lin Ng Carmen Chak-Lui Wong Chun-Ming Wong Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
description	Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge. Here, the authors show that phosphoglycerate dehydrogenase, a key enzyme in the serine synthesis pathway, drives sorafenib resistance.
format	article
author	Lai Wei Derek Lee Cheuk-Ting Law Misty Shuo Zhang Jialing Shen Don Wai-Ching Chin Allen Zhang Felice Ho-Ching Tsang Ceci Lok-Sze Wong Irene Oi-Lin Ng Carmen Chak-Lui Wong Chun-Ming Wong
author_facet	Lai Wei Derek Lee Cheuk-Ting Law Misty Shuo Zhang Jialing Shen Don Wai-Ching Chin Allen Zhang Felice Ho-Ching Tsang Ceci Lok-Sze Wong Irene Oi-Lin Ng Carmen Chak-Lui Wong Chun-Ming Wong
author_sort	Lai Wei
title	Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
title_short	Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
title_full	Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
title_fullStr	Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
title_full_unstemmed	Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC
title_sort	genome-wide crispr/cas9 library screening identified phgdh as a critical driver for sorafenib resistance in hcc
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1f27ce98d13a42cd9355ac519e4b7c2f
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Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

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