The prevalence of rheumatoid arthritis in Spain

Abstract Rheumatoid arthritis (RA) prevalence is believed to be around 1% worldwide, although it varies considerably among different populations. The aim of EPISER2016 study was to estimate the prevalence of RA in the general adult population in Spain. We designed a population-based cross-sectional...

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Autores principales:	Lucía Silva-Fernández, Cristina Macía-Villa, Daniel Seoane-Mato, Raúl Cortés-Verdú, Antonio Romero-Pérez, Víctor Quevedo-Vila, Dolores Fábregas-Canales, Fred Antón-Pagés, Gustavo Añez, Anahy Brandy, Cristina Martínez-Dubois, Paula Rubio-Muñoz, Carlos Sánchez-Piedra, Federico Díaz-González, Sagrario Bustabad-Reyes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f2837e5d13747f98581833e5553601c
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spelling	oai:doaj.org-article:1f2837e5d13747f98581833e5553601c2021-12-02T15:11:50ZThe prevalence of rheumatoid arthritis in Spain10.1038/s41598-020-76511-62045-2322https://doaj.org/article/1f2837e5d13747f98581833e5553601c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-76511-6https://doaj.org/toc/2045-2322Abstract Rheumatoid arthritis (RA) prevalence is believed to be around 1% worldwide, although it varies considerably among different populations. The aim of EPISER2016 study was to estimate the prevalence of RA in the general adult population in Spain. We designed a population-based cross-sectional study. A national survey was conducted between November 2016 and October 2017 involving a probabilistic sample from the general population aged 20 years or older. Subjects were randomly selected for phone screening using a computer-assisted telephone interviewer system. Positive RA screening results were evaluated by a rheumatologist. Cases fulfilled the 1987 ACR and/or the 2010 ACR/EULAR criteria; previous diagnosis established by a rheumatologist and clearly identified in medical records were also accepted regardless of the criteria used. Prevalence estimates with 95% CI were calculated taking into account the design of the sample (weighting based on age, sex, and geographic origin using as a reference the distribution of the population in Spain). 4916 subjects participated in the study and 39 RA cases were confirmed. RA estimated prevalence was 0.82% (95% CI 0.59–1.15). Mean age of RA cases was 60.48 (14.85) years, they were more frequently women (61.5%), from urban areas (74.4%), non-smokers (43.6%), and with a high body mass index (53.8% with overweight). Extrapolating to the population in Spain (approximately 37 million are ≥ 20 years old), it was estimated that there were between 220,000 and 430,000 people aged 20 years or older with RA. No undiagnosed cases were detected, which could be related to the establishment of early arthritis clinics around the country, increasing the rates of diagnosis during early phases of RA.Lucía Silva-FernándezCristina Macía-VillaDaniel Seoane-MatoRaúl Cortés-VerdúAntonio Romero-PérezVíctor Quevedo-VilaDolores Fábregas-CanalesFred Antón-PagésGustavo AñezAnahy BrandyCristina Martínez-DuboisPaula Rubio-MuñozCarlos Sánchez-PiedraFederico Díaz-GonzálezSagrario Bustabad-ReyesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lucía Silva-Fernández Cristina Macía-Villa Daniel Seoane-Mato Raúl Cortés-Verdú Antonio Romero-Pérez Víctor Quevedo-Vila Dolores Fábregas-Canales Fred Antón-Pagés Gustavo Añez Anahy Brandy Cristina Martínez-Dubois Paula Rubio-Muñoz Carlos Sánchez-Piedra Federico Díaz-González Sagrario Bustabad-Reyes The prevalence of rheumatoid arthritis in Spain
description	Abstract Rheumatoid arthritis (RA) prevalence is believed to be around 1% worldwide, although it varies considerably among different populations. The aim of EPISER2016 study was to estimate the prevalence of RA in the general adult population in Spain. We designed a population-based cross-sectional study. A national survey was conducted between November 2016 and October 2017 involving a probabilistic sample from the general population aged 20 years or older. Subjects were randomly selected for phone screening using a computer-assisted telephone interviewer system. Positive RA screening results were evaluated by a rheumatologist. Cases fulfilled the 1987 ACR and/or the 2010 ACR/EULAR criteria; previous diagnosis established by a rheumatologist and clearly identified in medical records were also accepted regardless of the criteria used. Prevalence estimates with 95% CI were calculated taking into account the design of the sample (weighting based on age, sex, and geographic origin using as a reference the distribution of the population in Spain). 4916 subjects participated in the study and 39 RA cases were confirmed. RA estimated prevalence was 0.82% (95% CI 0.59–1.15). Mean age of RA cases was 60.48 (14.85) years, they were more frequently women (61.5%), from urban areas (74.4%), non-smokers (43.6%), and with a high body mass index (53.8% with overweight). Extrapolating to the population in Spain (approximately 37 million are ≥ 20 years old), it was estimated that there were between 220,000 and 430,000 people aged 20 years or older with RA. No undiagnosed cases were detected, which could be related to the establishment of early arthritis clinics around the country, increasing the rates of diagnosis during early phases of RA.
format	article
author	Lucía Silva-Fernández Cristina Macía-Villa Daniel Seoane-Mato Raúl Cortés-Verdú Antonio Romero-Pérez Víctor Quevedo-Vila Dolores Fábregas-Canales Fred Antón-Pagés Gustavo Añez Anahy Brandy Cristina Martínez-Dubois Paula Rubio-Muñoz Carlos Sánchez-Piedra Federico Díaz-González Sagrario Bustabad-Reyes
author_facet	Lucía Silva-Fernández Cristina Macía-Villa Daniel Seoane-Mato Raúl Cortés-Verdú Antonio Romero-Pérez Víctor Quevedo-Vila Dolores Fábregas-Canales Fred Antón-Pagés Gustavo Añez Anahy Brandy Cristina Martínez-Dubois Paula Rubio-Muñoz Carlos Sánchez-Piedra Federico Díaz-González Sagrario Bustabad-Reyes
author_sort	Lucía Silva-Fernández
title	The prevalence of rheumatoid arthritis in Spain
title_short	The prevalence of rheumatoid arthritis in Spain
title_full	The prevalence of rheumatoid arthritis in Spain
title_fullStr	The prevalence of rheumatoid arthritis in Spain
title_full_unstemmed	The prevalence of rheumatoid arthritis in Spain
title_sort	prevalence of rheumatoid arthritis in spain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f2837e5d13747f98581833e5553601c
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The prevalence of rheumatoid arthritis in Spain

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