A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma

Abstract Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, but the prognosis of LUAD patients remains unsatisfactory. Here, we retrieved the RNA-seq data of LUAD cohort from The Cancer Genome Atlas (TCGA) database and then identified differentially expressed immune-related lncRNA...

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Autores principales:	Yang Liu, Qiuhong Wu, Xuejiao Fan, Wen Li, Xiaogang Li, Hui Zhu, Qinghua Zhou, Jinming Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f2d11b1a6944011849ac4e2cf652885
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spelling	oai:doaj.org-article:1f2d11b1a6944011849ac4e2cf6528852021-12-02T16:45:41ZA novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma10.1038/s41598-021-96236-42045-2322https://doaj.org/article/1f2d11b1a6944011849ac4e2cf6528852021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96236-4https://doaj.org/toc/2045-2322Abstract Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, but the prognosis of LUAD patients remains unsatisfactory. Here, we retrieved the RNA-seq data of LUAD cohort from The Cancer Genome Atlas (TCGA) database and then identified differentially expressed immune-related lncRNAs (DEirlncRNAs) between LUAD and normal controls. Based on a new method of cyclically single pairing along with a 0-or-1 matrix, we constructed a novel prognostic signature of 8 DEirlncRNA pairs in LUAD with no dependence upon specific expression levels of lncRNAs. This prognostic model exhibited significant power in distinguishing good or poor prognosis of LUAD patients and the values of the area under the curve (AUC) were all over 0.70 in 1, 3, 5 years receiver operating characteristic (ROC) curves. Moreover, the risk score of the model could serve as an independent prognostic factor for patients with LUAD. In addition, the risk model was significantly associated with clinicopathological characteristics, tumor-infiltrating immune cells, immune-related molecules and sensitivity of anti-tumor drugs. This novel signature of DEirlncRNA pairs in LUAD, which did not require specific expression levels of lncRNAs, might be used to guide the administration of patients with LUAD in clinical practice.Yang LiuQiuhong WuXuejiao FanWen LiXiaogang LiHui ZhuQinghua ZhouJinming YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Liu Qiuhong Wu Xuejiao Fan Wen Li Xiaogang Li Hui Zhu Qinghua Zhou Jinming Yu A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
description	Abstract Lung adenocarcinoma (LUAD) is the most common subtype of lung cancer, but the prognosis of LUAD patients remains unsatisfactory. Here, we retrieved the RNA-seq data of LUAD cohort from The Cancer Genome Atlas (TCGA) database and then identified differentially expressed immune-related lncRNAs (DEirlncRNAs) between LUAD and normal controls. Based on a new method of cyclically single pairing along with a 0-or-1 matrix, we constructed a novel prognostic signature of 8 DEirlncRNA pairs in LUAD with no dependence upon specific expression levels of lncRNAs. This prognostic model exhibited significant power in distinguishing good or poor prognosis of LUAD patients and the values of the area under the curve (AUC) were all over 0.70 in 1, 3, 5 years receiver operating characteristic (ROC) curves. Moreover, the risk score of the model could serve as an independent prognostic factor for patients with LUAD. In addition, the risk model was significantly associated with clinicopathological characteristics, tumor-infiltrating immune cells, immune-related molecules and sensitivity of anti-tumor drugs. This novel signature of DEirlncRNA pairs in LUAD, which did not require specific expression levels of lncRNAs, might be used to guide the administration of patients with LUAD in clinical practice.
format	article
author	Yang Liu Qiuhong Wu Xuejiao Fan Wen Li Xiaogang Li Hui Zhu Qinghua Zhou Jinming Yu
author_facet	Yang Liu Qiuhong Wu Xuejiao Fan Wen Li Xiaogang Li Hui Zhu Qinghua Zhou Jinming Yu
author_sort	Yang Liu
title	A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
title_short	A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
title_full	A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
title_fullStr	A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
title_full_unstemmed	A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma
title_sort	novel prognostic signature of immune-related lncrna pairs in lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1f2d11b1a6944011849ac4e2cf652885
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A novel prognostic signature of immune-related lncRNA pairs in lung adenocarcinoma

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