Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract

Abstract Background Epithelial-mesenchymal transition (EMT) helps solid tumors to lose their intercellular adhesive property and drives metastasis. As mangosteen fruit is known for many beneficial effects including antimicrobial, antioxidant, and anti-tumorigenic properties and has been used widely...

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Autores principales:	Suganthi Muralidharan, Adaikkalam Vellaichamy
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Mangosteen rind Breast cancer Epithelial-mesenchymal transition Apoptosis Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1f30456047924727a8393b7cc4d0edef
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spelling	oai:doaj.org-article:1f30456047924727a8393b7cc4d0edef2021-11-08T11:04:36ZEvaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract10.1186/s43094-021-00368-32314-7253https://doaj.org/article/1f30456047924727a8393b7cc4d0edef2021-11-01T00:00:00Zhttps://doi.org/10.1186/s43094-021-00368-3https://doaj.org/toc/2314-7253Abstract Background Epithelial-mesenchymal transition (EMT) helps solid tumors to lose their intercellular adhesive property and drives metastasis. As mangosteen fruit is known for many beneficial effects including antimicrobial, antioxidant, and anti-tumorigenic properties and has been used widely in traditional medicine, we interrogated its possible anti-metastatic effect on MCF-7 breast cancer cells. Results We found that aqueous mangosteen rind extract (MRE) inhibited growth of MCF-7 and altered the transcript levels of ERα, ERβ, and EGFR genes. Additionally, the MRE changed the expression of important markers of EMT, E-Cadherin, N-Cadherin, Snail, and MMP-9. Moreover, MRE inhibited migration of MCF-7 cells. Conclusion The results suggest that MRE suppresses growth and inhibits epithelial-mesenchymal transition in MCF-7 cells.Suganthi MuralidharanAdaikkalam VellaichamySpringerOpenarticleMangosteen rindBreast cancerEpithelial-mesenchymal transitionApoptosisTherapeutics. PharmacologyRM1-950Pharmacy and materia medicaRS1-441ENFuture Journal of Pharmaceutical Sciences, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mangosteen rind Breast cancer Epithelial-mesenchymal transition Apoptosis Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441
spellingShingle	Mangosteen rind Breast cancer Epithelial-mesenchymal transition Apoptosis Therapeutics. Pharmacology RM1-950 Pharmacy and materia medica RS1-441 Suganthi Muralidharan Adaikkalam Vellaichamy Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract
description	Abstract Background Epithelial-mesenchymal transition (EMT) helps solid tumors to lose their intercellular adhesive property and drives metastasis. As mangosteen fruit is known for many beneficial effects including antimicrobial, antioxidant, and anti-tumorigenic properties and has been used widely in traditional medicine, we interrogated its possible anti-metastatic effect on MCF-7 breast cancer cells. Results We found that aqueous mangosteen rind extract (MRE) inhibited growth of MCF-7 and altered the transcript levels of ERα, ERβ, and EGFR genes. Additionally, the MRE changed the expression of important markers of EMT, E-Cadherin, N-Cadherin, Snail, and MMP-9. Moreover, MRE inhibited migration of MCF-7 cells. Conclusion The results suggest that MRE suppresses growth and inhibits epithelial-mesenchymal transition in MCF-7 cells.
format	article
author	Suganthi Muralidharan Adaikkalam Vellaichamy
author_facet	Suganthi Muralidharan Adaikkalam Vellaichamy
author_sort	Suganthi Muralidharan
title	Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract
title_short	Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract
title_full	Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract
title_fullStr	Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract
title_full_unstemmed	Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract
title_sort	evaluation of anti-epithelial-mesenchymal transition property of garcinia mangostana rind extract
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/1f30456047924727a8393b7cc4d0edef
work_keys_str_mv	AT suganthimuralidharan evaluationofantiepithelialmesenchymaltransitionpropertyofgarciniamangostanarindextract AT adaikkalamvellaichamy evaluationofantiepithelialmesenchymaltransitionpropertyofgarciniamangostanarindextract
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Evaluation of anti-epithelial-mesenchymal transition property of Garcinia mangostana rind extract

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