Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel

Katherine Vorvolakos1, Irada S Isayeva1, Hoan-My Do Luu1, Dinesh V Patwardhan1, Steven K Pollack21Division of Chemistry and Material Science, 2Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USAAbstract: Hya...

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Autores principales:	Katherine Vorvolakos, Irada S Isayeva, Hoan-My Do Luu, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/1f31353cf2934f49bfeaecf8be9e8c97
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spelling	oai:doaj.org-article:1f31353cf2934f49bfeaecf8be9e8c972021-12-02T00:51:07ZIonically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel1179-1470https://doaj.org/article/1f31353cf2934f49bfeaecf8be9e8c972010-12-01T00:00:00Zhttp://www.dovepress.com/ionically-cross-linked-hyaluronic-acid-wetting-lubrication-and-viscoel-a5923https://doaj.org/toc/1179-1470Katherine Vorvolakos1, Irada S Isayeva1, Hoan-My Do Luu1, Dinesh V Patwardhan1, Steven K Pollack21Division of Chemistry and Material Science, 2Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USAAbstract: Hyaluronic acid (HA), in linear or cross-linked form, is a common component of cosmetics, personal care products, combination medical products, and medical devices. In all cases, the ability of the HA solution or gel to wet surfaces and/or disrupt and lubricate interfaces is a limiting feature of its mechanism of action. We synthesized ferric ion&ndash;cross-linked networks of HA based on an adhesion barrier, varied the degree of cross-linking, and performed wetting goniometry, viscometry, and dynamic mechanical analysis. As cross-linking increases, so do contact angle, viscosity, storage modulus, and loss modulus; thus, wetting and lubrication are compromised. These findings have implications in medical device materials, such as adhesion barriers and mucosal drug delivery vehicles.Keywords: hyaluron, adhesion barrier, wetting, contact angle, viscosity, lubrication, elasticity, viscoelastic, hydrogel, ferric Katherine VorvolakosIrada S IsayevaHoan-My Do Luuet alDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2011, Iss default, Pp 1-10 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Katherine Vorvolakos Irada S Isayeva Hoan-My Do Luu et al Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
description	Katherine Vorvolakos1, Irada S Isayeva1, Hoan-My Do Luu1, Dinesh V Patwardhan1, Steven K Pollack21Division of Chemistry and Material Science, 2Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USAAbstract: Hyaluronic acid (HA), in linear or cross-linked form, is a common component of cosmetics, personal care products, combination medical products, and medical devices. In all cases, the ability of the HA solution or gel to wet surfaces and/or disrupt and lubricate interfaces is a limiting feature of its mechanism of action. We synthesized ferric ion&ndash;cross-linked networks of HA based on an adhesion barrier, varied the degree of cross-linking, and performed wetting goniometry, viscometry, and dynamic mechanical analysis. As cross-linking increases, so do contact angle, viscosity, storage modulus, and loss modulus; thus, wetting and lubrication are compromised. These findings have implications in medical device materials, such as adhesion barriers and mucosal drug delivery vehicles.Keywords: hyaluron, adhesion barrier, wetting, contact angle, viscosity, lubrication, elasticity, viscoelastic, hydrogel, ferric
format	article
author	Katherine Vorvolakos Irada S Isayeva Hoan-My Do Luu et al
author_facet	Katherine Vorvolakos Irada S Isayeva Hoan-My Do Luu et al
author_sort	Katherine Vorvolakos
title	Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
title_short	Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
title_full	Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
title_fullStr	Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
title_full_unstemmed	Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
title_sort	ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/1f31353cf2934f49bfeaecf8be9e8c97
work_keys_str_mv	AT katherinevorvolakos ionicallycrosslinkedhyaluronicacidwettinglubricationandviscoelasticityofamodifiedadhesionbarriergel AT iradasisayeva ionicallycrosslinkedhyaluronicacidwettinglubricationandviscoelasticityofamodifiedadhesionbarriergel AT hoanmydoluu ionicallycrosslinkedhyaluronicacidwettinglubricationandviscoelasticityofamodifiedadhesionbarriergel AT etal ionicallycrosslinkedhyaluronicacidwettinglubricationandviscoelasticityofamodifiedadhesionbarriergel
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Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel

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