Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that promotes HIV-1 replication and reversal of lat...

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Autores principales:	Hany Zekaria Meås, Markus Haug, Marianne Sandvold Beckwith, Claire Louet, Liv Ryan, Zhenyi Hu, Johannes Landskron, Svein Arne Nordbø, Kjetil Taskén, Hang Yin, Jan Kristian Damås, Trude Helen Flo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f33f39d7271470fa221c346a06d3977
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spelling	oai:doaj.org-article:1f33f39d7271470fa221c346a06d39772021-12-02T17:32:57ZSensing of HIV-1 by TLR8 activates human T cells and reverses latency10.1038/s41467-019-13837-42041-1723https://doaj.org/article/1f33f39d7271470fa221c346a06d39772020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13837-4https://doaj.org/toc/2041-1723Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that promotes HIV-1 replication and reversal of latency.Hany Zekaria MeåsMarkus HaugMarianne Sandvold BeckwithClaire LouetLiv RyanZhenyi HuJohannes LandskronSvein Arne NordbøKjetil TaskénHang YinJan Kristian DamåsTrude Helen FloNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hany Zekaria Meås Markus Haug Marianne Sandvold Beckwith Claire Louet Liv Ryan Zhenyi Hu Johannes Landskron Svein Arne Nordbø Kjetil Taskén Hang Yin Jan Kristian Damås Trude Helen Flo Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
description	Manipulation of Toll-like receptors (TLRs) affects HIV-1 infection and latency reversal. Here, the authors show that HIV-1 is endocytosed and recognized by TLR8 in human primary CD4+T cells and that TLR8 stimulation induces an inflammatory response that promotes HIV-1 replication and reversal of latency.
format	article
author	Hany Zekaria Meås Markus Haug Marianne Sandvold Beckwith Claire Louet Liv Ryan Zhenyi Hu Johannes Landskron Svein Arne Nordbø Kjetil Taskén Hang Yin Jan Kristian Damås Trude Helen Flo
author_facet	Hany Zekaria Meås Markus Haug Marianne Sandvold Beckwith Claire Louet Liv Ryan Zhenyi Hu Johannes Landskron Svein Arne Nordbø Kjetil Taskén Hang Yin Jan Kristian Damås Trude Helen Flo
author_sort	Hany Zekaria Meås
title	Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
title_short	Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
title_full	Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
title_fullStr	Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
title_full_unstemmed	Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
title_sort	sensing of hiv-1 by tlr8 activates human t cells and reverses latency
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f33f39d7271470fa221c346a06d3977
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Sensing of HIV-1 by TLR8 activates human T cells and reverses latency

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