RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation
RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis via ERK inhibition.
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Nature Portfolio
2018
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oai:doaj.org-article:1f3887098b28416d9c9f3a9d72788b252021-12-02T15:34:06ZRAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation10.1038/s41467-018-05941-82041-1723https://doaj.org/article/1f3887098b28416d9c9f3a9d72788b252018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05941-8https://doaj.org/toc/2041-1723RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis via ERK inhibition.Berta CasarAndrew P. BadrockIñaki JiménezImanol ArozarenaPaula Colón-BoleaL. Francisco Lorenzo-MartínIrene Barinaga-RementeríaJorge BarriusoVincenzo CappitelliDaniel J. DonoghueXosé R. BusteloAdam HurlstonePiero CrespoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Berta Casar Andrew P. Badrock Iñaki Jiménez Imanol Arozarena Paula Colón-Bolea L. Francisco Lorenzo-Martín Irene Barinaga-Rementería Jorge Barriuso Vincenzo Cappitelli Daniel J. Donoghue Xosé R. Bustelo Adam Hurlstone Piero Crespo RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation |
| description |
RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis via ERK inhibition. |
| format |
article |
| author |
Berta Casar Andrew P. Badrock Iñaki Jiménez Imanol Arozarena Paula Colón-Bolea L. Francisco Lorenzo-Martín Irene Barinaga-Rementería Jorge Barriuso Vincenzo Cappitelli Daniel J. Donoghue Xosé R. Bustelo Adam Hurlstone Piero Crespo |
| author_facet |
Berta Casar Andrew P. Badrock Iñaki Jiménez Imanol Arozarena Paula Colón-Bolea L. Francisco Lorenzo-Martín Irene Barinaga-Rementería Jorge Barriuso Vincenzo Cappitelli Daniel J. Donoghue Xosé R. Bustelo Adam Hurlstone Piero Crespo |
| author_sort |
Berta Casar |
| title |
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation |
| title_short |
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation |
| title_full |
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation |
| title_fullStr |
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation |
| title_full_unstemmed |
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation |
| title_sort |
ras at the golgi antagonizes malignant transformation through ptprκ-mediated inhibition of erk activation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/1f3887098b28416d9c9f3a9d72788b25 |
| work_keys_str_mv |
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