Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease

Abstract We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson’s disease. Twenty-six Parkinson’s disease patients with bilateral subthalamic nucleus stimulation in a stable state were tested under stimulation off a...

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Autores principales:	Kai Li, Rocco Haase, Heinz Rüdiger, Manja Reimann, Heinz Reichmann, Martin Wolz, Tjalf Ziemssen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1f39c092572e4726af7d3f25ea17a758
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spelling	oai:doaj.org-article:1f39c092572e4726af7d3f25ea17a7582021-12-02T16:06:55ZSubthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease10.1038/s41598-017-07429-92045-2322https://doaj.org/article/1f39c092572e4726af7d3f25ea17a7582017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07429-9https://doaj.org/toc/2045-2322Abstract We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson’s disease. Twenty-six Parkinson’s disease patients with bilateral subthalamic nucleus stimulation in a stable state were tested under stimulation off and dopaminergic medication off (OFF-OFF), stimulation on and dopaminergic medication off (ON-OFF), and stimulation on and medication (levodopa) on (ON-ON) conditions by recording continuously blood pressure, ECG, and respiration at rest, during metronomic deep breathing, and head-up tilt test. Thirteen patients were diagnosed as orthostatic hypotension by head-up tilt test. Baroreflex sensitivity and spectral analyses were performed by trigonometric regressive spectral analysis. Subthalamic nucleus stimulation and levodopa had multiple influences. (1) Systolic blood pressure during tilt-up was reduced by subthalamic nucleus stimulation, and then further by levodopa. (2) Subthalamic nucleus stimulation and levodopa had different effects on sympathetic and parasympathetic regulations in Parkinson’s disease. (3) Levodopa decreased baroreflex sensitivity and RR interval only in the orthostatic hypotension group, and had opposite effects on the non-orthostatic hypotension group. These findings indicate that subthalamic nucleus stimulation and levodopa have different effects on cardiovascular autonomic function in Parkinson’s disease, which are modulated by the presence of orthostatic hypotension as well.Kai LiRocco HaaseHeinz RüdigerManja ReimannHeinz ReichmannMartin WolzTjalf ZiemssenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Li Rocco Haase Heinz Rüdiger Manja Reimann Heinz Reichmann Martin Wolz Tjalf Ziemssen Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease
description	Abstract We aimed to explore the effects of bilateral subthalamic nucleus stimulation and levodopa on cardiovascular autonomic function in Parkinson’s disease. Twenty-six Parkinson’s disease patients with bilateral subthalamic nucleus stimulation in a stable state were tested under stimulation off and dopaminergic medication off (OFF-OFF), stimulation on and dopaminergic medication off (ON-OFF), and stimulation on and medication (levodopa) on (ON-ON) conditions by recording continuously blood pressure, ECG, and respiration at rest, during metronomic deep breathing, and head-up tilt test. Thirteen patients were diagnosed as orthostatic hypotension by head-up tilt test. Baroreflex sensitivity and spectral analyses were performed by trigonometric regressive spectral analysis. Subthalamic nucleus stimulation and levodopa had multiple influences. (1) Systolic blood pressure during tilt-up was reduced by subthalamic nucleus stimulation, and then further by levodopa. (2) Subthalamic nucleus stimulation and levodopa had different effects on sympathetic and parasympathetic regulations in Parkinson’s disease. (3) Levodopa decreased baroreflex sensitivity and RR interval only in the orthostatic hypotension group, and had opposite effects on the non-orthostatic hypotension group. These findings indicate that subthalamic nucleus stimulation and levodopa have different effects on cardiovascular autonomic function in Parkinson’s disease, which are modulated by the presence of orthostatic hypotension as well.
format	article
author	Kai Li Rocco Haase Heinz Rüdiger Manja Reimann Heinz Reichmann Martin Wolz Tjalf Ziemssen
author_facet	Kai Li Rocco Haase Heinz Rüdiger Manja Reimann Heinz Reichmann Martin Wolz Tjalf Ziemssen
author_sort	Kai Li
title	Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease
title_short	Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease
title_full	Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease
title_fullStr	Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease
title_full_unstemmed	Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease
title_sort	subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1f39c092572e4726af7d3f25ea17a758
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Subthalamic nucleus stimulation and levodopa modulate cardiovascular autonomic function in Parkinson’s disease

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