Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations

Animal performance is determined by the functionality and health of the gastrointestinal tract (GIT). Complex mechanisms and interactions are involved in the regulation of GIT functionality and health. The understanding of these relationships could be crucial for developing strategies to improve ani...

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Autores principales:	Federico Ghiselli, Barbara Rossi, Andrea Piva, Ester Grilli
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	intestinal health gut barrier farm animal ex vivo model in vitro model Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/1f3a3d41eea646d09a564c8dab2959a2
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spelling	oai:doaj.org-article:1f3a3d41eea646d09a564c8dab2959a22021-11-30T12:31:51ZAssessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations2297-176910.3389/fvets.2021.723387https://doaj.org/article/1f3a3d41eea646d09a564c8dab2959a22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.723387/fullhttps://doaj.org/toc/2297-1769Animal performance is determined by the functionality and health of the gastrointestinal tract (GIT). Complex mechanisms and interactions are involved in the regulation of GIT functionality and health. The understanding of these relationships could be crucial for developing strategies to improve animal production yields. The concept of “gut health" is not well defined, but this concept has begun to play a very important role in the field of animal science. However, a clear definition of GIT health and the means by which to measure it are lacking. In vitro and ex vivo models can facilitate these studies, creating well-controlled and repeatable conditions to understand how to improve animal gut health. Over the years, several models have been developed and used to study the beneficial or pathogenic relationships between the GIT and the external environment. This review aims to describe the most commonly used animals' in vitro or ex vivo models and techniques that are useful for better understanding the intestinal health of production animals, elucidating their benefits and limitations.Federico GhiselliBarbara RossiAndrea PivaAndrea PivaEster GrilliEster GrilliFrontiers Media S.A.articleintestinal healthgut barrierfarm animalex vivo modelin vitro modelVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestinal health gut barrier farm animal ex vivo model in vitro model Veterinary medicine SF600-1100
spellingShingle	intestinal health gut barrier farm animal ex vivo model in vitro model Veterinary medicine SF600-1100 Federico Ghiselli Barbara Rossi Andrea Piva Andrea Piva Ester Grilli Ester Grilli Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations
description	Animal performance is determined by the functionality and health of the gastrointestinal tract (GIT). Complex mechanisms and interactions are involved in the regulation of GIT functionality and health. The understanding of these relationships could be crucial for developing strategies to improve animal production yields. The concept of “gut health" is not well defined, but this concept has begun to play a very important role in the field of animal science. However, a clear definition of GIT health and the means by which to measure it are lacking. In vitro and ex vivo models can facilitate these studies, creating well-controlled and repeatable conditions to understand how to improve animal gut health. Over the years, several models have been developed and used to study the beneficial or pathogenic relationships between the GIT and the external environment. This review aims to describe the most commonly used animals' in vitro or ex vivo models and techniques that are useful for better understanding the intestinal health of production animals, elucidating their benefits and limitations.
format	article
author	Federico Ghiselli Barbara Rossi Andrea Piva Andrea Piva Ester Grilli Ester Grilli
author_facet	Federico Ghiselli Barbara Rossi Andrea Piva Andrea Piva Ester Grilli Ester Grilli
author_sort	Federico Ghiselli
title	Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations
title_short	Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations
title_full	Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations
title_fullStr	Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations
title_full_unstemmed	Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations
title_sort	assessing intestinal health. in vitro and ex vivo gut barrier models of farm animals: benefits and limitations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1f3a3d41eea646d09a564c8dab2959a2
work_keys_str_mv	AT federicoghiselli assessingintestinalhealthinvitroandexvivogutbarriermodelsoffarmanimalsbenefitsandlimitations AT barbararossi assessingintestinalhealthinvitroandexvivogutbarriermodelsoffarmanimalsbenefitsandlimitations AT andreapiva assessingintestinalhealthinvitroandexvivogutbarriermodelsoffarmanimalsbenefitsandlimitations AT andreapiva assessingintestinalhealthinvitroandexvivogutbarriermodelsoffarmanimalsbenefitsandlimitations AT estergrilli assessingintestinalhealthinvitroandexvivogutbarriermodelsoffarmanimalsbenefitsandlimitations AT estergrilli assessingintestinalhealthinvitroandexvivogutbarriermodelsoffarmanimalsbenefitsandlimitations
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Assessing Intestinal Health. In Vitro and Ex vivo Gut Barrier Models of Farm Animals: Benefits and Limitations

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