Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis

Bovine leukemia virus (BLV) is an oncogenic retrovirus of the Deltaretrovirus genus, which causes persistent infection in its natural hosts – cattle, zebu, and water buffalo with diverse clinical manifestations through the defeat of B-cells. The BLV proviral genome, along with structural genes (gag,...

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Autores principales:	Irina M. Zyrianova, Svetlana N. Kovalchuk
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	bovine leukemia virus (blv) tax gene tax protein polymorphism enzootic bovine leukosis (ebl) Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/1f3a952da7c24e088d5c5480909942d5
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spelling	oai:doaj.org-article:1f3a952da7c24e088d5c5480909942d52021-11-17T14:21:57ZBovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis2150-55942150-560810.1080/21505594.2019.1708051https://doaj.org/article/1f3a952da7c24e088d5c5480909942d52020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2019.1708051https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608Bovine leukemia virus (BLV) is an oncogenic retrovirus of the Deltaretrovirus genus, which causes persistent infection in its natural hosts – cattle, zebu, and water buffalo with diverse clinical manifestations through the defeat of B-cells. The BLV proviral genome, along with structural genes (gag, pro, pol, and env), includes nonstructural ones (R3, G4, tax, rex, AS, pre-miRs (for miRNAs). We have shown in our previous data the association of some pre-miRs-B’ (for BLV miRNA) alleles with leukocyte (WBC – white blood cell) number in BLV-infected cows. Multifunctional properties of Tax protein have led us to an assumption that tax gene/Tax protein could have too population variations related to WBC counts. Here we report about several tax alleles/Tax protein variants, which have a highly significant association with an increase or a decrease of WBC number in BLV-infected cows. We have provided evidence that Tax A, H variants (tax b, c, d, f, e alleles) are correlated with reduced WBC counts at the level of BLV-negative groups of animals and thus could be the feature of the aleukemic (AL) form of BLV infection. We suggest this finding could be used in BLV testing for the presence of Tax A, H in the proviral DNA consider such strains of BLV as AL ones, and because of this, minimize the clinical losses due to BLV infection in cattle.Irina M. ZyrianovaSvetlana N. KovalchukTaylor & Francis Grouparticlebovine leukemia virus (blv)tax genetax proteinpolymorphismenzootic bovine leukosis (ebl)Infectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 80-87 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	bovine leukemia virus (blv) tax gene tax protein polymorphism enzootic bovine leukosis (ebl) Infectious and parasitic diseases RC109-216
spellingShingle	bovine leukemia virus (blv) tax gene tax protein polymorphism enzootic bovine leukosis (ebl) Infectious and parasitic diseases RC109-216 Irina M. Zyrianova Svetlana N. Kovalchuk Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis
description	Bovine leukemia virus (BLV) is an oncogenic retrovirus of the Deltaretrovirus genus, which causes persistent infection in its natural hosts – cattle, zebu, and water buffalo with diverse clinical manifestations through the defeat of B-cells. The BLV proviral genome, along with structural genes (gag, pro, pol, and env), includes nonstructural ones (R3, G4, tax, rex, AS, pre-miRs (for miRNAs). We have shown in our previous data the association of some pre-miRs-B’ (for BLV miRNA) alleles with leukocyte (WBC – white blood cell) number in BLV-infected cows. Multifunctional properties of Tax protein have led us to an assumption that tax gene/Tax protein could have too population variations related to WBC counts. Here we report about several tax alleles/Tax protein variants, which have a highly significant association with an increase or a decrease of WBC number in BLV-infected cows. We have provided evidence that Tax A, H variants (tax b, c, d, f, e alleles) are correlated with reduced WBC counts at the level of BLV-negative groups of animals and thus could be the feature of the aleukemic (AL) form of BLV infection. We suggest this finding could be used in BLV testing for the presence of Tax A, H in the proviral DNA consider such strains of BLV as AL ones, and because of this, minimize the clinical losses due to BLV infection in cattle.
format	article
author	Irina M. Zyrianova Svetlana N. Kovalchuk
author_facet	Irina M. Zyrianova Svetlana N. Kovalchuk
author_sort	Irina M. Zyrianova
title	Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis
title_short	Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis
title_full	Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis
title_fullStr	Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis
title_full_unstemmed	Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis
title_sort	bovine leukemia virus tax gene/tax protein polymorphism and its relation to enzootic bovine leukosis
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/1f3a952da7c24e088d5c5480909942d5
work_keys_str_mv	AT irinamzyrianova bovineleukemiavirustaxgenetaxproteinpolymorphismanditsrelationtoenzooticbovineleukosis AT svetlanankovalchuk bovineleukemiavirustaxgenetaxproteinpolymorphismanditsrelationtoenzooticbovineleukosis
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Bovine leukemia virus tax gene/Tax protein polymorphism and its relation to Enzootic Bovine Leukosis

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