Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synth...

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Autores principales:	Anlian Zhu, Xin Li, Lili Bai, Gongming Zhu, Yuanyang Guo, Jianwei Lin, Yiwen Cui, Gaofei Tian, Lihe Zhang, Jianji Wang, Xiang David Li, Lingjun Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1f3c4c9b9d4d4c23b09e955f0979915c
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spelling	oai:doaj.org-article:1f3c4c9b9d4d4c23b09e955f0979915c2021-12-02T15:39:25ZBiomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides10.1038/s41467-020-19409-12041-1723https://doaj.org/article/1f3c4c9b9d4d4c23b09e955f0979915c2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19409-1https://doaj.org/toc/2041-1723ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.Anlian ZhuXin LiLili BaiGongming ZhuYuanyang GuoJianwei LinYiwen CuiGaofei TianLihe ZhangJianji WangXiang David LiLingjun LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anlian Zhu Xin Li Lili Bai Gongming Zhu Yuanyang Guo Jianwei Lin Yiwen Cui Gaofei Tian Lihe Zhang Jianji Wang Xiang David Li Lingjun Li Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
description	ADP-ribosylated peptides are important molecular tools, however, the lack of effective synthetic methods hinders the access to their complex structures. Here, the authors present a biomimetic α-selective ribosylation reaction coupled with click chemistry ultimately providing a two-step modular synthesis of α-ADP-ribosylated peptides.
format	article
author	Anlian Zhu Xin Li Lili Bai Gongming Zhu Yuanyang Guo Jianwei Lin Yiwen Cui Gaofei Tian Lihe Zhang Jianji Wang Xiang David Li Lingjun Li
author_facet	Anlian Zhu Xin Li Lili Bai Gongming Zhu Yuanyang Guo Jianwei Lin Yiwen Cui Gaofei Tian Lihe Zhang Jianji Wang Xiang David Li Lingjun Li
author_sort	Anlian Zhu
title	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_short	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_full	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_fullStr	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_full_unstemmed	Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides
title_sort	biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important adp-ribosylated peptides
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1f3c4c9b9d4d4c23b09e955f0979915c
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Biomimetic α-selective ribosylation enables two-step modular synthesis of biologically important ADP-ribosylated peptides

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