Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study

Introduction: Atherosclerosis is an inflammatory disease and is one of the leading causes of cardiovascular disease. Vascular plaques are formed on the inner surface of hardened arteries and gradually develop, reducing the diameter of the arteries. CXCR4 is one of the most important chemokine recept...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hanieh Nikkhah, Maryam Vafaei, Ehsan Farashahi Yazd, Fatemeh Arjmand, Ensieh Shahvazian, Mohammad Bagher Mahmoodi, Abbas Andishmand
Formato:	article
Lenguaje:	FA
Publicado:	Shahid Sadoughi University of Medical Sciences 2021
Materias:	atherosclerosis polymorphism rs2228014 cxcr4 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1f3ed2d9b9fa4bf18807863c561d3071
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1f3ed2d9b9fa4bf18807863c561d3071
record_format	dspace
spelling	oai:doaj.org-article:1f3ed2d9b9fa4bf18807863c561d30712021-11-15T07:41:20ZAssociation between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study2228-57412228-5733https://doaj.org/article/1f3ed2d9b9fa4bf18807863c561d30712021-11-01T00:00:00Zhttp://jssu.ssu.ac.ir/article-1-5139-en.htmlhttps://doaj.org/toc/2228-5741https://doaj.org/toc/2228-5733Introduction: Atherosclerosis is an inflammatory disease and is one of the leading causes of cardiovascular disease. Vascular plaques are formed on the inner surface of hardened arteries and gradually develop, reducing the diameter of the arteries. CXCR4 is one of the most important chemokine receptors, whose presence has been confirmed in cardiac plaques. Our aim was to determine the relationship between genetic diversity of CXCR4 gene (rs2228014) and atherosclerosis among the population of patients. Methods: The present study included 254 participants who referred to the Cardiac Angiography Department of Afshar Hospital in Yazd City. The main criteria for admission to the case group were coronary artery stenosis with angiography testing, and in the control group, the clients did not have coronary artery disease. The age and sex matching of the two groups were considered. Blood specimens were taken, and after DNA extraction, the SNP genotype of the CXCR4 gene was determined using ARMS-PCR. Statistical analysis of the data carried out using SPSS software version 19 and Chi-square test. Results: Genetic models of rs2228014 variant were evaluated in patients with atherosclerosis in comparison with the control group and a significant difference between allelic (P = 0.333), homozygous (P = 0.087), heterozygous (P = 849.0), dominant (P = 0.570) and recessive (P = 0.086) genetic models of rs2228014 polymorphism was not observed. Conclusion: In the current study, no significant difference was observed between genetic models of rs222801 polymorphism in patients with atherosclerosis and healthy individuals. Based on our findings, the rs222801 polymorphism of the CXCR4 gene might not be considered as a predisposing factor for atherosclerosis.Hanieh NikkhahMaryam VafaeiEhsan Farashahi YazdFatemeh ArjmandEnsieh ShahvazianMohammad Bagher MahmoodiAbbas AndishmandShahid Sadoughi University of Medical Sciencesarticleatherosclerosispolymorphismrs2228014cxcr4Medicine (General)R5-920FAMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, Vol 29, Iss 8, Pp 4013-4020 (2021)
institution	DOAJ
collection	DOAJ
language	FA
topic	atherosclerosis polymorphism rs2228014 cxcr4 Medicine (General) R5-920
spellingShingle	atherosclerosis polymorphism rs2228014 cxcr4 Medicine (General) R5-920 Hanieh Nikkhah Maryam Vafaei Ehsan Farashahi Yazd Fatemeh Arjmand Ensieh Shahvazian Mohammad Bagher Mahmoodi Abbas Andishmand Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study
description	Introduction: Atherosclerosis is an inflammatory disease and is one of the leading causes of cardiovascular disease. Vascular plaques are formed on the inner surface of hardened arteries and gradually develop, reducing the diameter of the arteries. CXCR4 is one of the most important chemokine receptors, whose presence has been confirmed in cardiac plaques. Our aim was to determine the relationship between genetic diversity of CXCR4 gene (rs2228014) and atherosclerosis among the population of patients. Methods: The present study included 254 participants who referred to the Cardiac Angiography Department of Afshar Hospital in Yazd City. The main criteria for admission to the case group were coronary artery stenosis with angiography testing, and in the control group, the clients did not have coronary artery disease. The age and sex matching of the two groups were considered. Blood specimens were taken, and after DNA extraction, the SNP genotype of the CXCR4 gene was determined using ARMS-PCR. Statistical analysis of the data carried out using SPSS software version 19 and Chi-square test. Results: Genetic models of rs2228014 variant were evaluated in patients with atherosclerosis in comparison with the control group and a significant difference between allelic (P = 0.333), homozygous (P = 0.087), heterozygous (P = 849.0), dominant (P = 0.570) and recessive (P = 0.086) genetic models of rs2228014 polymorphism was not observed. Conclusion: In the current study, no significant difference was observed between genetic models of rs222801 polymorphism in patients with atherosclerosis and healthy individuals. Based on our findings, the rs222801 polymorphism of the CXCR4 gene might not be considered as a predisposing factor for atherosclerosis.
format	article
author	Hanieh Nikkhah Maryam Vafaei Ehsan Farashahi Yazd Fatemeh Arjmand Ensieh Shahvazian Mohammad Bagher Mahmoodi Abbas Andishmand
author_facet	Hanieh Nikkhah Maryam Vafaei Ehsan Farashahi Yazd Fatemeh Arjmand Ensieh Shahvazian Mohammad Bagher Mahmoodi Abbas Andishmand
author_sort	Hanieh Nikkhah
title	Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study
title_short	Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study
title_full	Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study
title_fullStr	Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study
title_full_unstemmed	Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study
title_sort	association between rs2228014 polymorphism of cxcr4 and coronary artery atherosclerosis: a case-control study
publisher	Shahid Sadoughi University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/1f3ed2d9b9fa4bf18807863c561d3071
work_keys_str_mv	AT haniehnikkhah associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy AT maryamvafaei associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy AT ehsanfarashahiyazd associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy AT fatemeharjmand associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy AT ensiehshahvazian associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy AT mohammadbaghermahmoodi associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy AT abbasandishmand associationbetweenrs2228014polymorphismofcxcr4andcoronaryarteryatherosclerosisacasecontrolstudy
_version_	1718428480347045888

Association between rs2228014 Polymorphism of CXCR4 and Coronary Artery Atherosclerosis: A Case-Control Study

Ejemplares similares